ArticleJournal of diabetes investigation2019
Low serum creatinine and risk of diabetes: The Japan Epidemiology Collaboration on Occupational Health Study.
Article in Journal of diabetes investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- The association between adult height and the incidence of diabetes in a Japanese working population: a prospective study exploring the possible role of cohort effects.BMC public health · 2026Article
- Beyond linearity: a threshold effect links serum creatinine to SIRI in osteoporotic fractures.Frontiers in medicine · 2025Article
- Unraveling hypoglycemia risk during hemodialysis: a predictive model from a nested case-control study.Frontiers in physiology · 2025Article
- Clinical study of different prediction models in predicting diabetic nephropathy in patients with type 2 diabetes mellitus.World journal of diabetes · 2024Article
- Article
- Association between serum creatinine and type 2 diabetes in the Chinese population: a retrospective cohort study.Scientific reports · 2023Article
- Association of serum creatinine levels and risk of type 2 diabetes mellitus in Korea: a case control study.BMC endocrine disorders · 2022Article
- The Association Between the Triglyceride-to-High-Density Lipoprotein Cholesterol Ratio and the Risk of Progression to Diabetes From Prediabetes: A 5-year Cohort Study in Chinese Adults.Frontiers in endocrinology · 2022Article
- Prevalence and Characteristics of Prediabetes and Metabolic Syndrome in Seemingly Healthy Persons at a Health Check-Up Clinic.Journal of multidisciplinary healthcare · 2022Article
- Optimization of a GC-MS method for the profiling of microbiota-dependent metabolites in blood samples: An application to type 2 diabetes and prediabetes.Frontiers in molecular biosciences · 2022Article
- Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction.International journal of environmental research and public health · 2021Article
- Determinants of Longitudinal Change of Glycated Hemoglobin in a Large Non-Diabetic Population.Journal of personalized medicine · 2021Article
- A Study of Creatinine Level among Patients with Dyslipidemia and Type 2 Diabetes Mellitus using Multilayer Perceptron and Multiple Linear Regression.Journal of pharmacy & bioallied sciences · 2021Article
- Role and Risk Factors of Glycosylated Hemoglobin Levels in Early Disease Screening.Journal of diabetes research · 2021Article
- Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study.Journal of clinical medicine · 2020Article
- Low serum creatinine and risk of diabetes: The Japan Epidemiology Collaboration on Occupational Health Study.Journal of diabetes investigation · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 10 institutions in 2 countries.
Funding
Abstract
AIMS/
introductionWe examined a prospective association between serum creatinine levels and diabetes. MATERIALS AND
methodsThe present study included 31,343 male workers without diabetes, and aged between 20 and 64 years at baseline. We calculated the cumulative average of their serum creatinine over the study period. We defined diabetes as either glycated hemoglobin levels ≥6.5%, random glucose levels ≥200 mg/dL, fasting glucose levels ≥126 mg/dL or receiving antidiabetic treatment. Cox proportional hazards regression analysis was carried out to estimate the hazard ratio (HR) and 95% confidence interval (CI).
resultsWith a median observation of 7.7 years, 2,509 participants developed diabetes. After adjusting for age, smoking, body mass index, hypertension and dyslipidemia, lower cumulative average serum creatinine levels were related to a greater diabetes risk: HRs were 1.56 (95% CI 1.35-1.82), 1.22 (1.09-1.35) and 1.06 (0.96-1.17) for the participants with serum creatinine <0.70, 0.70-0.79 and 0.80-0.89 mg/dL, respectively, compared with those with 0.90-1.20 mg/dL (P for trend <0.001). The serum creatinine-diabetes association was more pronounced among older adults (serum creatinine <0.70 vs 0.90-1.20 mg/dL, HR 1.66, 95% CI 1.37-2.00) than younger adults (HR 1.32, 95% CI 1.02-1.71; P for interaction by age group = 0.001).
conclusionsLow serum creatinine is associated with an increased risk of diabetes. Screening serum creatinine levels can be used to identify those who are at high risk of diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.