Evidence map›Paper›PMID 30756423›Full record

Observational studyThe Journal of dermatology2019

Atopic dermatitis disease registry in Japanese adult patients with moderate to severe atopic dermatitis (ADDRESS-J): Baseline characteristics, treatment history and disease burden.

Norito Katoh, Hidehisa Saeki, Yoko Kataoka, Takafumi Etoh, Satoshi Teramukai, Hiroki Takagi, Yuki Tajima, Marius Ardeleanu, Elena Rizova, Kazuhiko Arima and 1 more

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in The Journal of dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
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  3. Observational
  4. Review
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  7. Observational
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  12. Article
  13. Observational
  14. Review
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Article
  20. Nomenclature and clinical phenotypes of atopic dermatitis.Therapeutic advances in chronic disease · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

Norito KatohDepartment of Dermatology, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID https://orcid.org/0000-0002-3498-2482
Hidehisa SaekiDepartment of Dermatology, Nippon Medical School, Tokyo, Japan.ORCID https://orcid.org/0000-0002-1095-0355
Yoko KataokaDepartment of Dermatology, Osaka Habikino Medical Center, Osaka, Japan.
Takafumi EtohDepartment of Dermatology, Tokyo Teishin Hospital, Tokyo, Japan.
Satoshi TeramukaiDepartment of Biostatistics, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID https://orcid.org/0000-0003-2184-0597
Hiroki TakagiSanofi K.K., Tokyo, Japan.
Yuki TajimaSanofi K.K., Tokyo, Japan.
Marius ArdeleanuRegeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Elena RizovaSanofi Genzyme, Cambridge, Massachusetts, USA.
Kazuhiko ArimaSanofi K.K., Tokyo, Japan.ORCID https://orcid.org/0000-0002-0607-8787
ADDRESS-J Investigators
Sanofi (Japan) · JPKyoto Prefectural University of Medicine · JPAssociates in Neurology · USNippon Medical School · JPOsaka Prefectural Medical Center · JPRegeneron (United States) · USSanofi (United States) · USTokyo Teishin Hospital · JP

Funding

Regeneron PharmaceuticalsSanofi Genzyme
6 · The paper itself

Abstract

Moderate to severe atopic dermatitis (AD) has a high disease burden and a significant effect on quality of life. Observational studies are necessary to determine the patient disease burden and long-term disease control in the Japanese population. ADDRESS-J is a non-interventional, observational registry of adult Japanese patients with moderate to severe AD. Herein, we report baseline data from the ADDRESS-J study describing disease characteristics and current treatment practices. At baseline, 300 adult AD patients with Investigator's Global Assessment (IGA) scores (range, 0-4) of 3 (moderate) or 4 (severe) whose treatments for AD were intensified, were assessed for clinical and patient-reported outcomes and current AD treatments. The registry patients' median age was 34.0 years; 60.7% were male and 71.7% had had AD for more than 20 years. At baseline, 220 study patients had an IGA score of 3 and 80 had an IGA score of 4. The median Eczema Area and Severity Index score was 21.7 (range, 0-72), the median body surface area involvement was 46.25%, and the median pruritus numerical rating scale score was 7.0 (range, 0-10); for each of these measures, higher scores represent greater severity. Most registry patients (86.7%) had recently used topical corticosteroids or topical calcineurin inhibitors as treatment for AD. This registry cohort represents a population of Japanese patients with moderate to severe AD and provides an important resource for characterizing the disease burden and evaluating the safety and effectiveness of various AD treatments.

Indexed as

Cost of IllnessAdministration, CutaneousAdultCalcineurin InhibitorsDermatitis, AtopicDermatologic AgentsFemaleGlucocorticoidsHumansJapanLongitudinal StudiesMaleMiddle AgedPatient Reported Outcome MeasuresProspective StudiesQuality of LifeCalcineurin InhibitorsDermatologic AgentsGlucocorticoidsadultatopic dermatitisburden of diseaseJapanregistry

Identifiers

PMID30756423
PMCPMC6594225
OpenAlexW2914198163

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.