ArticleBritish journal of clinical pharmacology2019
Fluid volume kinetics of 20% albumin.
Article in British journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Intravascular volume expansion is prominently overestimated via hemoglobin concentration: a placebo-controlled and cross-over trial.Pflugers Archiv : European journal of physiology · 2025Trial
- Twenty percent human albumin solution fluid bolus administration therapy in patients after cardiac surgery-II: a multicentre randomised controlled trial.Intensive care medicine · 2024Trial
- Kinetics of 5% and 20% albumin: A controlled crossover trial in volunteers.Acta anaesthesiologica Scandinavica · 2022Trial
- Volume kinetic analysis of fluid retention after induction of general anesthesia.BMC anesthesiology · 2020Trial
- Albumin 20% in surgical and critically ill patients; a comprehensive review.Critical care (London, England) · 2026Review
- Albumin kinetics, intravascular fluid volume, and respiratory function in pigs ventilated at different levels of mechanical power following crystalloid vs. albumin infusion.Intensive care medicine experimental · 2026Article
- Intraoperative albumin use and postoperative acute kidney injury in patients undergoing noncardiac surgery.Scientific reports · 2025Article
- Constant plasma volume and colloid osmotic pressure after infusion of albumin 20%: A secondary analysis.Physiological reports · 2025Article
- Temporal Decline in Intravascular Albumin Mass and Its Association with Fluid Balance and Mortality in Sepsis: A Prospective Observational Study.Journal of clinical medicine · 2025Article
- Estimating the plasma volume by infusing albumin: a retrospective feasibility study.Intensive care medicine experimental · 2025Article
- Diuretic responses to Ringer's solution and 20% albumin at different arterial pressures.Physiological reports · 2024Article
- Capillary leak and endothelial permeability in critically ill patients: a current overview.Intensive care medicine experimental · 2023Review
- Dehydration before Major Urological Surgery and the Perioperative Pattern of Plasma Creatinine: A Prospective Cohort Series.Journal of clinical medicine · 2021Article
- Albumin as a drug: its biological effects beyond volume expansion.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2020Review
- Understanding Volume Kinetics: The Role of Pharmacokinetic Modeling and Analysis in Fluid Therapy.Frontiers in veterinary science · 2020Review
- Fluid volume kinetics of 20% albumin.British journal of clinical pharmacology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsA population kinetic model was developed for the body fluid shifts occurring when 20% albumin is given by intravenous infusion. The aim was to study whether its efficacy to expand the plasma volume is impaired after major surgery.
methodsAn intravenous infusion of 3 mL/kg 20% albumin over 30 minutes was given to 15 volunteers and to 15 patients on the 1
resultsThe rise in plasma albumin expanded the plasma volume in excess of the infused volume by relocating noncirculating fluid (rate constant k
conclusionsThere were no clinically relevant differences in the kinetics of 20% albumin between postoperative patients and volunteers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.