ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2019
Differentiation Between Guillain-Barré Syndrome and Acute-Onset Chronic Inflammatory Demyelinating Polyradiculoneuritis-a Prospective Follow-up Study Using Ultrasound and Neurophysiological Measurements.
Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Ultrasound assessment of peripheral nerve size in Guillain-Barré syndrome: A systematic review and Meta-Analysis.Neuroradiology · 2026Pooled it
- Role of Imaging in Chronic Inflammatory Demyelinating Polyneuropathy: A Systematic Review.European journal of neurology · 2025Pooled it
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Comprehensive Review of Types, Pathophysiology, and Treatment Approaches.Brain and behavior · 2026Review
- Lessons from a Severe Case of Fulminant Guillain-Barré Syndrome: A Case Report.Reports (MDPI) · 2026Article
- Article
- Polyradiculoneuropathies associated with immune checkpoint inhibitors: are we facing a new nosological entity?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Comparison of Different Ultrasound Protocols in Patients with Inflammatory Polyneuropathies with Practical Insights.Diagnostics (Basel, Switzerland) · 2025Article
- Guillain-Barré syndrome.Nature reviews. Disease primers · 2024Article
- Differentiating recurrent Guillain-Barre syndrome and acute-onset chronic inflammatory polyneuropathy: literature review.Acta neurologica Belgica · 2024Review
- Neurophysiological and Ultrasound Correlations in Guillain Barré Syndrome and CIDP-Case Series.Journal of personalized medicine · 2024Article
- A rare presentation of acute-onset chronic inflammatory demyelinating polyneuropathy with the detection of anti-GM3 and anti-sulfatides antibodies: a case report.Frontiers in immunology · 2024Article
- Reccurent guillain barré syndrome after COVID-19.Neurosciences (Riyadh, Saudi Arabia) · 2023Article
- Vagal cross-sectional area correlates with parasympathetic dysfunction in Parkinson's disease.Brain communications · 2023Article
- Enlarged cross-sectional area of the left vagus nerve in patients with major depressive disorder.Frontiers in psychiatry · 2023Article
- Nerve Imaging, Electrodiagnostics, and Clinical Examination - Three Musketeers to Differentiate Polyneuropathies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Article
- Postpartum attacks of acute-onset chronic inflammatory demyelinating polyneuropathy in a young woman with successive pregnancies.Quantitative imaging in medicine and surgery · 2021Article
- The ataxic neuropathies.Journal of neurology · 2021Review
- Nerve Ultrasound as Helpful Tool in Polyneuropathies.Diagnostics (Basel, Switzerland) · 2021Review
- Nerve ultrasound can identify treatment-responsive chronic neuropathies without electrodiagnostic features of demyelination.Muscle & nerve · 2019Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differentiation of Guillain-Barré syndrome (GBS) and acute-onset chronic inflammatory demyelinating polyradiculoneuritis (CIDP) might be intricate in early stages. We compared electrodiagnostics (EDx) and nerve ultrasound (NUS) as tools for early distinction and follow-up. NUS and EDx have been performed at first visitation and after 6 months. The nerve conduction study score (NCSS), the ultrasound pattern sum score (UPSS), and clinical scores were used for comparison. Compared with the 33 GBS patients, the 34 CIDP patients (50% with symptoms < 4 weeks) revealed significant nerve enlargement in ultrasound (p < 0.001) except for the roots and vagus, which exhibited increased values in both groups. EDx has no significant differences between both groups except for the A-wave frequency and the sural sparing pattern, which is more frequent in GBS (Fisher's exact p < 0.05). In the latter, particularly, pure sensory nerves were not enlarged in contrast to CIDP, in which those were mostly enlarged (p < 0.001). This ultrasonic sensory sparing pattern (uSSP) in combination with enlarged roots/vagus is the hallmark finding in GBS with sensitivity, specificity, and positive predictive value > 85%, whereas in CIDP, enlarged sensory und multifocally enlarged sensorimotor nerves are key differentiation features to GBS. Increased echointensity of the nerves further arises only in CIDP. After 6 months, in CIDP, the significant nerve enlargement persisted, whereas in GBS, all segments almost normalized. Clinical, ultrasonic, and NCS scores correlated significantly over the time. Enlarged roots/vagus in combination with uSSP might facilitate differentiation of GBS and CIDP in the early stage, and ultrasonic 6-month normalization underlines the diagnosis of GBS in cases of uncertainty. Trial Registration: DRKS-ID 00005253.
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