ArticleCognitive, affective & behavioral neuroscience2019
Psychosis risk is associated with decreased resting-state functional connectivity between the striatum and the default mode network.
Article in Cognitive, affective & behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Deficit of satellite oligodendrocytes of neurons in the rostral part of the head of the caudate nucleus in schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Altered cortical-striatal circuits connectivity is associated with psychotic symptoms in patients with first-episode, drug-naïve early-onset schizophrenia.Frontiers in psychiatry · 2025Article
- Addressing brain metabolic connectivity in treatment-resistant schizophrenia: a novel graph theory-driven application ofSchizophrenia (Heidelberg, Germany) · 2024Article
- Size and Topography of the Brain's Functional Networks with Psychotic Experiences, Schizophrenia, and Bipolar Disorder.Biological psychiatry global open science · 2024Article
- Mild Behavioral Impairment in Parkinson's Disease: An Updated Review on the Clinical, Genetic, Neuroanatomical, and Pathophysiological Aspects.Medicina (Kaunas, Lithuania) · 2024Review
- High-Frequency Transcranial Random Noise Stimulation Modulates Gamma-Band EEG Source-Based Large-Scale Functional Network Connectivity in Patients with Schizophrenia: A Randomized, Double-Blind, Sham-Controlled Clinical Trial.Journal of personalized medicine · 2022Article
- Reward enhances connectivity between the ventral striatum and the default mode network.NeuroImage · 2022Article
- Gray-Matter Morphometry of Internalizing-Symptom Dimensions During Adolescence.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Abnormal functional connectivity of the striatum in first-episode drug-naive early-onset Schizophrenia.Brain and behavior · 2022Article
- Aberrant default mode connectivity in adolescents with early-onset psychosis: A resting state fMRI study.NeuroImage. Clinical · 2022Article
- Alcohol use in daily life: Examining the role of trait and state impulsivity facets.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021Article
- Psychosis risk is associated with decreased white matter integrity in limbic network corticostriatal tracts.Psychiatry research. Neuroimaging · 2020Article
- Mild behavioral impairment in Parkinson's disease is associated with altered corticostriatal connectivity.NeuroImage. Clinical · 2020Article
- Psychosis risk is associated with decreased resting-state functional connectivity between the striatum and the default mode network.Cognitive, affective & behavioral neuroscience · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Psychosis is linked to aberrant salience or to viewing neutral stimuli as self-relevant, suggesting a possible impairment in self-relevance processing. Psychosis is also associated with increased dopamine in the dorsal striatum, especially the anterior caudate (Kegeles et al., 2010). Critically, the anterior caudate is especially connected to (a) the cortical default mode network (DMN), centrally involved in self-relevance processing, and (b) to a lesser extent, the cortical frontoparietal network (FPN; Choi, Yeo, & Buckner, 2012). However, no previous study has directly examined striatal-cortical DMN connectivity in psychosis risk. In Study 1, we examined resting-state functional connectivity in psychosis risk (n = 18) and control (n = 19) groups between (a) striatal DMN and FPN subregions and (b) cortical DMN and FPN. The psychosis risk group exhibited decreased connectivity between the striatal subregions and the cortical DMN. In contrast, the psychosis risk group exhibited intact connectivity between the striatal subregions and the cortical FPN. Additionally, recent distress was also associated with decreased striatal-cortical DMN connectivity. In Study 2, to determine whether the decreased striatal-cortical DMN connectivity was specific to psychosis risk or was related to recent distress more generally, we examined the relationship between connectivity and distress in individuals diagnosed with nonpsychotic emotional distress disorders (N = 25). In contrast to Study 1, here we found that distress was associated with evidence of increased striatal-cortical DMN connectivity. Overall, the present results suggest that decreased striatal-cortical DMN connectivity is associated with psychosis risk and could contribute to aberrant salience.
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