Evidence map›Paper›PMID 30755811›Full record

ArticleAmerican journal of cancer research2019

Antibody and fragment-based PET imaging of CTLA-4+ T-cells in humanized mouse models.

Emily B Ehlerding, Hye Jin Lee, Dawei Jiang, Carolina A Ferreira, Christopher D Zahm, Peng Huang, Jonathan W Engle, Douglas G McNeel, Weibo Cai

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Review
  5. Imaging Immunotherapy.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
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  8. Review
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  11. Article
  12. Review
  13. MRI techniques for immunotherapy monitoring.Journal for immunotherapy of cancer · 2022
    Review
  14. Review
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  16. Review
  17. miR-4759 suppresses breast cancer through immune checkpoint blockade.Computational and structural biotechnology journal · 2022
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Emily B EhlerdingDepartment of Medical Physics, University of Wisconsin-Madison Madison, WI 53705, USA.
Hye Jin LeePharmaceutical Sciences Department, University of Wisconsin-Madison Madison, WI 53705, USA.
Dawei JiangDepartment of Radiology, University of Wisconsin-Madison Madison, WI 53705, USA.
Carolina A FerreiraDepartment of Biomedical Engineering, University of Wisconsin-Madison Madison, WI 53705, USA.
Christopher D ZahmCarbone Cancer Center, University of Wisconsin-Madison Madison, WI 53705, USA.
Peng HuangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University Shenzhen 518060, China.
Jonathan W EngleDepartment of Medical Physics, University of Wisconsin-Madison Madison, WI 53705, USA.
Douglas G McNeelCarbone Cancer Center, University of Wisconsin-Madison Madison, WI 53705, USA.
Weibo CaiDepartment of Medical Physics, University of Wisconsin-Madison Madison, WI 53705, USA.
University of Wisconsin–Madison · USShenzhen University · CNUniversity of Wisconsin Carbone Cancer Center · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Nihal Ahmad · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
NCI NIH HHS P30 CA014520NCI NIH HHS T32 CA009206NIGMS NIH HHS T32 GM008505
6 · The paper itself

Abstract

Imaging of immunotherapy targets using positron emission tomography (PET) can allow for noninvasive monitoring of their dynamic expression and may allow for patient stratification in the future. Therefore, two tracers targeting CTLA-4, one a full antibody and the other a F(ab')

Indexed as

64Cuantibody fragmentcheckpoint immunotherapyCytotoxic T-lymphocyte-associated antigen 4 (CTLA-4)humanized miceipilimumabpositron emission tomography (PET)

Identifiers

PMID30755811
PMCPMC6356917
OpenAlexW2994168084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.