Evidence map›Paper›PMID 30755766›Full record

ArticleContrast media & molecular imaging2019

Detection of Active Caspase-3 in Mouse Models of Stroke and Alzheimer's Disease with a Novel Dual Positron Emission Tomography/Fluorescent Tracer [

Valeriy G Ostapchenko, Jonatan Snir, Mojmir Suchy, Jue Fan, M Rebecca Cobb, Blaine A Chronik, Michael Kovacs, Vania F Prado, Robert H E Hudson, Stephen H Pasternak and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contrast media & molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease.International journal of molecular sciences · 2023
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Peptides for trans-blood-brain barrier delivery.Journal of labelled compounds & radiopharmaceuticals · 2023
    Review
  6. Article
  7. Molecular Imaging of Apoptosis: The Case of Caspase-3 Radiotracers.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Synthesis, Radiolabeling, and Preliminary in vivo Evaluation of [Drug design, development and therapy · 2021
    Article
  10. Development of [Cancers · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Valeriy G OstapchenkoRobarts Research Institute, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7.ORCID 0000-0002-3629-7702
Jonatan SnirRobarts Research Institute, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7.
Mojmir SuchyRobarts Research Institute, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7.
Jue FanRobarts Research Institute, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7.
M Rebecca CobbRobarts Research Institute, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7.
Blaine A ChronikDepartment of Medical Biophysics, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7.
Michael KovacsDepartment of Medical Biophysics, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7.
Vania F PradoRobarts Research Institute, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7.
Robert H E HudsonDepartment of Chemistry, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7.ORCID 0000-0003-2360-6024
Stephen H PasternakRobarts Research Institute, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7.
Marco A M PradoRobarts Research Institute, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7.ORCID 0000-0002-3028-5778
Robert BarthaRobarts Research Institute, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7.ORCID 0000-0002-7118-9096
Western University · CA

Funding

CIHR MOP 126000CIHR MOP 136930CIHR MOP 89919
6 · The paper itself

Abstract

Apoptosis is a feature of stroke and Alzheimer's disease (AD), yet there is no accepted method to detect or follow apoptosis in the brain in vivo. We developed a bifunctional tracer [

Indexed as

Alzheimer DiseaseAnimalsCaspase 3Cells, CulturedFemaleGallium RadioisotopesKineticsMaleMiceMicroscopy, ConfocalPositron-Emission TomographyStrokeCaspase 3Gallium Radioisotopes

Identifiers

PMID30755766
PMCPMC6348924
OpenAlexW2909035282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.