Evidence map›Paper›PMID 30755699›Full record

ArticleScientific reports2019

Ghrelin Receptor Influence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl-Ghrelin.

Cody J Wenthur, Ritika Gautam, Bin Zhou, Leandro F Vendruscolo, Lorenzo Leggio, Kim D Janda

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Ghrelin decreases sensitivity to negative feedback and increases prediction-error related caudate activity in humans, a randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial
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  12. Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine DThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  13. The Role of Ghrelin/GHS-R1A Signaling in Nonalcohol Drug Addictions.International journal of molecular sciences · 2022
    Review
  14. Review
  15. Ghrelin Signaling: GOAT and GHS-R1a Take a LEAP in Complexity.Trends in endocrinology and metabolism: TEM · 2020
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cody J WenthurDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Ritika GautamDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Bin ZhouDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Leandro F VendruscoloNeurobiology of Addiction Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Lorenzo LeggioSection on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Kim D JandaDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. kdjanda@scripps.edu.

Funding

Evaluation of Liposomal Nicotine Vaccines for Repeated Pulmonary AdministrationF32DA043323 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI WENTHUR, CODY JAMES · 2017 to 2018
$80k
NIDA NIH HHS F32 DA043323
6 · The paper itself

Abstract

The peptide hormone acyl-ghrelin and its receptor, GHSR

Indexed as

AnimalsAppetiteBlood-Brain BarrierCentral Nervous SystemCocaineCravingEnergy MetabolismGhrelinHumansMaleMiceReceptors, GhrelinRewardSignal TransductionWeight Gainacyl-ghrelinCocaineGhrelinGhsr1a protein, humanReceptors, Ghrelin

Identifiers

PMID30755699
PMCPMC6372697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.