ArticleScientific reports2019
Metabotyping as a Stopover in Genome-to-Phenome Mapping.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A pennycress transparent testa 8 knockout mutant has drastic changes in seed coat anatomy and chemical compositions.Journal of experimental botany · 2026Article
- Multiomic Integration Analysis for Monitoring Severe Asthma Treated With Mepolizumab or Omalizumab.Allergy · 2025Article
- Patterns of pan-genome occupancy and gene coexpression under water-deficit in Brachypodium distachyon.Molecular ecology · 2022Article
- Targeted and Untargeted Metabolomic Analyses Reveal Organ Specificity of Specialized Metabolites in the Model GrassMolecules (Basel, Switzerland) · 2022Article
- Activation of the plant mevalonate pathway by extracellular ATP.Nature communications · 2022Article
- Article
- Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype.Molecular systems biology · 2021Article
- Metabolomics for Biomarker Discovery: Key Signatory Metabolic Profiles for the Identification and Discrimination of Oat Cultivars.Metabolites · 2021Article
- Phenolic Metabolites from Barley in Contribution to Phenome in soil Moisture Deficit.International journal of molecular sciences · 2020Article
- The metabolome as a link in the genotype-phenotype map for peroxide resistance in the fruit fly, Drosophila melanogaster.BMC genomics · 2020Article
- Plant Biosystems Design for a Carbon-Neutral Bioeconomy.Biodesign research · 2020Review
- Genetic Variation for Seed Metabolite Levels inInternational journal of molecular sciences · 2019Article
- Metabolomics: Paving the path for personalized periodontics - A literature review.Journal of Indian Society of PeriodontologyReview
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Predicting phenotypic expression from genomic and environmental information is arguably the greatest challenge in today's biology. Being able to survey genomic content, e.g., as single-nucleotide polymorphism data, within a diverse population and predict the phenotypes of external traits, represents the holy grail across genome-informed disciplines, from personal medicine and nutrition to plant breeding. In the present study, we propose a two-step procedure in bridging the genome to phenome gap where external phenotypes are viewed as emergent properties of internal phenotypes, such as molecular profiles, in interaction with the environment. Using biomass accumulation and shoot-root allometry as external traits in diverse genotypes of the model grass Brachypodium distachyon, we established correlative models between genotypes and metabolite profiles (metabotypes) as internal phenotypes, and between metabotypes and external phenotypes under two contrasting watering regimes. Our results demonstrate the potential for employing metabotypes as an integrator in predicting external phenotypes from genomic information.
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