Evidence map›Paper›PMID 30755658›Full record

ArticleScientific reports2019

Distinct Subsets of Lateral Hypothalamic Neurotensin Neurons are Activated by Leptin or Dehydration.

Juliette A Brown, Anna Wright, Raluca Bugescu, Lyndsay Christensen, David P Olson, Gina M Leinninger

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Structure and function of neocortical layer 6b.Frontiers in cellular neuroscience · 2023
    Review
  13. Review
  14. Leptin signaling and leptin resistance.Medical review (2021) · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Thirst recruits phasic dopamine signaling through subfornical organ neurons.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Juliette A BrownMichigan State University Department of Pharmacology and Toxicology, East Lansing, 48824, MI, USA.
Anna WrightMichigan State University Department of Physiology, East Lansing, 48824, MI, USA.
Raluca BugescuMichigan State University Department of Physiology, East Lansing, 48824, MI, USA.
Lyndsay ChristensenDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
David P OlsonDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, 48109, USA.
Gina M LeinningerInstitute for Integrative Toxicology at Michigan State University, East Lansing, 48824, MI, USA. leinning@msu.edu.
Michigan State University · USUniversity of Michigan–Ann Arbor · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
MULTIDISCIPLINARY TRAINING IN ENVIRONMENTAL TOXICOLOGYT32ES007255 · NIEHS · MICHIGAN STATE UNIVERSITY · PI JOHN J LAPRES · 1989 to 2026
$9.3M
Role of Lateral Hypothalamic Neurotensin Neurons in Energy BalanceR01DK103808 · NIDDK · MICHIGAN STATE UNIVERSITY · PI Gina Marie Leinninger · 2014 to 2026
$4.8M
Role of Neurotensin Neurons in Coordinating Adaptive Energy BalanceF31DK107081 · NIDDK · MICHIGAN STATE UNIVERSITY · PI BROWN, JULIETTE ANNE · 2015 to 2017
$57k
NIDDK NIH HHS F31 DK107081NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK103808NIEHS NIH HHS T32 ES007255U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) T32-ES00725527
6 · The paper itself

Abstract

The lateral hypothalamic area (LHA) is essential for ingestive behavior but it remains unclear how LHA neurons coordinate feeding vs. drinking. Most LHA populations promote food and water consumption but LHA neurotensin (Nts) neurons preferentially induce water intake while suppressing feeding. We identified two molecularly and projection-specified subpopulations of LHA Nts neurons that are positioned to coordinate either feeding or drinking. One subpopulation co-expresses the long form of the leptin receptor (LepRb) and is activated by the anorectic hormone leptin (Nts

Indexed as

Animal FeedAnimalsBrainColchicineDehydrationFeeding BehaviorFemaleGenotypeGreen Fluorescent ProteinsHypothalamic Area, LateralLeptinMaleMesencephalonMiceMice, Inbred C57BLNeuronsColchicineGreen Fluorescent ProteinsLeptinNeurotensinNeurotransmitter AgentsWater

Identifiers

PMID30755658
PMCPMC6372669
OpenAlexW2936069408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.