Trial reportScientific reports2019
Evaluation of vascular pain in patients with colorectal cancer receiving peripheral venous chemotherapy with or without oxaliplatin.
Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Lidocaine coinfusion alleviates vascular pain induced by hypertonic saline infusion: a randomized, placebo-controlled trial.BMC anesthesiology · 2021Trial
- Evaluation of postoperative pain by PainVision® PS-2100, a quantitative analyzer for perception and pain in pulmonary resection: a prospective pilot study.Journal of anesthesia · 2026Article
- Salinomycin and oxaliplatin synergistically enhances cytotoxic effect on human colorectal cancer cells in vitro and in vivo.Scientific reports · 2025Article
- Eye Pain Caused by Epithelial Damage in the Central Cornea in Aqueous-Deficient Dry Eye.Diagnostics (Basel, Switzerland) · 2023Article
- Evaluation of perception threshold and pain in patients with Parkinson's disease using PainVisionFrontiers in neurology · 2023Article
- Optimal Timing of Intravenous Acetaminophen Administration for Postoperative Analgesia.Anesthesia progress · 2022Article
- Evaluation of Eye-Pain Severity between Dry-Eye Subtypes.Diagnostics (Basel, Switzerland) · 2021Article
- Analgesia by Sacral Surface Electrical Stimulation for Primary Dysmenorrhoea.Journal of rehabilitation medicine. Clinical communications · 2020Article
- New Method for the Quantitative Assessment of Sensory Disturbances in Cervical Myelopathy: Application for Neurological Level Diagnosis.Spine surgery and related research · 2020Article
- The Relationship Between Evaluation Methods for Chemotherapy-Induced Peripheral Neuropathy.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxaliplatin is a key chemotherapy drug in patients with colorectal cancer. Administration of oxaliplatin via a peripheral vein often causes vascular pain. However, no studies have evaluated vascular pain in patients with colorectal cancer in relation to peripheral venous administration of chemotherapy with or without oxaliplatin. We evaluated oxaliplatin-induced vascular pain using subjective and objective methods. We determined if oxaliplatin induced vascular pain in patients with colorectal cancer using a Visual Analog Scale (VAS) and a PainVision PS-2100 device. We compared VAS score between chemotherapy regimens with or without oxaliplatin, and between genders. We also examined the correlations of VAS score with pain intensity examined by the PainVision PS-2100, and with age and vessel diameter. A total of 98 patients with colorectal cancer were enrolled in this study, including 78 patients who received oxaliplatin via peripheral venous administration and 20 who received chemotherapy without oxaliplatin. The median VAS scores in patients with and without oxaliplatin were 36.5 (interquartile range 9.0-60.0) and 0 (0-4.0), respectively (P < 0.001), and the median pain intensities according to PainVision were 43.5 (14.3-98) and 36.5 (9.3-58.5), respectively (P < 0.001). There was a positive correlation between VAS and pain intensity (r = 0.584), but no correlation between VAS score and age (r = -0.174) or vessel diameter (r = -0.107). Peripheral venous administration of oxaliplatin induced vascular pain, measured both subjectively and objectively, in patients with colorectal cancer, regardless of vessel diameter.
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