ArticleTranslational psychiatry2019
Three-dimensional alteration of neurites in schizophrenia.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Hyperdynamic microtubule-based structural changes in Monocyte-Derived-Neuronal-like cells from patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2026Article
- Characterization of Social and Repetitive Behaviors of Mllt11/Af1q/TcF7c Conditional Knockout Mice.The European journal of neuroscience · 2026Article
- Structural alteration of neurons in schizophrenia and its relation with auditory hallucination.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Nano-laminography with a transmission X-ray microscope.Journal of synchrotron radiation · 2025Article
- Structural differences between human and mouse neurons and their implementation in generative AIs.Scientific reports · 2025Article
- Association between enhanced carbonyl stress and decreased apparent axonal density in schizophrenia by multimodal white matter imaging.Scientific reports · 2023Article
- Vascular-related biomarkers in psychosis: a systematic review and meta-analysis.Frontiers in psychiatry · 2023Review
- Article
- Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology.Communications biology · 2022Article
- Perinatal exposure to synergistic multiple stressors leads to cellular and behavioral deficits mimicking Schizophrenia-like pathology.Biology open · 2022Article
- Investigating the regulation of themicroPublication biology · 2022Article
- ULK4 in Neurodevelopmental and Neuropsychiatric Disorders.Frontiers in cell and developmental biology · 2022Review
- Schizophrenia-Mimicking Layers Outperform Conventional Neural Network Layers.Frontiers in neurorobotics · 2022Article
- Optimizing the energy bandwidth for transmission full-field X-ray microscopy experiments.Journal of synchrotron radiation · 2022Article
- Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures.Scientific reports · 2021Article
- Structural diverseness of neurons between brain areas and between cases.Translational psychiatry · 2021Article
- Glyoxalase 1 Confers Susceptibility to Schizophrenia: From Genetic Variants to Phenotypes of Neural Function.Frontiers in molecular neuroscience · 2021Article
- Molecular Basis of GABA Hypofunction in Adolescent Schizophrenia-Like Animals.Neural plasticity · 2021Article
- Three-dimensional architecture of human diabetic peripheral nerves revealed by X-ray phase contrast holographic nanotomography.Scientific reports · 2020Article
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Authors and funding
19 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychiatric symptoms of schizophrenia suggest alteration of cerebral neurons. However, the physical basis of the schizophrenia symptoms has not been delineated at the cellular level. Here, we report nanometer-scale three-dimensional analysis of brain tissues of schizophrenia and control cases. Structures of cerebral tissues of the anterior cingulate cortex were visualized with synchrotron radiation nanotomography. Tissue constituents visualized in the three-dimensional images were traced to build Cartesian coordinate models of tissue constituents, such as neurons and blood vessels. The obtained Cartesian coordinates were used for calculating curvature and torsion of neurites in order to analyze their geometry. Results of the geometric analyses indicated that the curvature of neurites is significantly different between schizophrenia and control cases. The mean curvature of distal neurites of the schizophrenia cases was ~1.5 times higher than that of the controls. The schizophrenia case with the highest neurite curvature carried a frame shift mutation in the GLO1 gene, suggesting that oxidative stress due to the GLO1 mutation caused the structural alteration of the neurites. The differences in the neurite curvature result in differences in the spatial trajectory and hence alter neuronal circuits. It has been shown that the anterior cingulate cortex analyzed in this study has emotional and cognitive functions. We suggest that the structural alteration of neurons in the schizophrenia cases should reflect psychiatric symptoms of schizophrenia.
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