Evidence map›Paper›PMID 30755518›Full record

ArticlemBio2019

Dual β-Lactam Combinations Highly Active against Mycobacterium abscessus Complex

R Pandey, L Chen, C Manca, S Jenkins, L Glaser, C Vinnard, G Stone, J Lee, B Mathema, E L Nuermberger and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Journal of bacteriology · 2026
    Review
  3. The Role of β-Lactam Antibiotics in Treating Mycobacterium abscessus: From Laboratory Insights to Clinical Applications and the Case for Clinical Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Novel C5α-substituted carbapenems enhanceAntimicrobial agents and chemotherapy · 2025
    Article
  11. Article
  12. Article
  13. Toward better cures forClinical microbiology reviews · 2024
    Review
  14. Multidrug-resistantAmerican journal of ophthalmology case reports · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Case Commentary: Dual β-lactam as part of regimen to treatAntimicrobial agents and chemotherapy · 2024
    Article
  19. Article
  20. Antimicrobial agents and chemotherapy · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

R PandeyPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
L ChenPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
C MancaPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
S JenkinsDepartment of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York, New York, USA.
L GlaserDepartment of Clinical Microbiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
C VinnardPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
G StonePfizer, Groton, Connecticut, USA.
J LeeDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
B MathemaDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
E L NuermbergerDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
R A BonomoMedical Service and GRECC, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
B N KreiswirthPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA kreiswba@njms.rutgers.edu.
Rutgers, The State University of New Jersey · USJohns Hopkins Medicine · USColumbia University · USCornell University · USHospital of the University of Pennsylvania · USLouis Stokes Cleveland VA Medical Center · USPfizer (United States) · US

Funding

Dissecting the molecular targets to overcome beta-lactam resistance in M. abscessus complexR01AI141805 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI BARRY Neal KREISWIRTH · 2019 to 2026
$5.1M
Exploiting a robust drug discovery portfolio to develop effective regimens to treat Mycobacterium abscessus lung infectionR21AI137814 · NIAID · JOHNS HOPKINS UNIVERSITY · PI NUERMBERGER, ERIC L · 2018 to 2019
$450k
NIAID NIH HHS R01 AI141805NIAID NIH HHS R21 AI137814
6 · The paper itself

Abstract

As a consequence of a growing population of immunocompromised individuals, including transplant recipients and cystic fibrosis patients, there has been a dramatic increase in chronic infections caused by

Indexed as

Drug SynergismAnti-Bacterial Agentsbeta-LactamsCeftarolineCeftazidimeCephalosporinsHumansImipenemMicrobial Sensitivity TestsMicrobial ViabilityModels, BiologicalMycobacterium abscessusMycobacterium Infections, NontuberculousTHP-1 CellsTreatment OutcomeAnti-Bacterial Agentsbeta-LactamsCeftarolineCeftazidimeCephalosporinsImipenembeta-lactamasesbeta-lactamsmultidrug resistanceMycobacterium abscessus

Identifiers

PMID30755518
PMCPMC6372805
OpenAlexW2914522129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.