Evidence map›Paper›PMID 30755509›Full record

ArticlemBio2019

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome.

Sara Botto, Jinu Abraham, Nobuyo Mizuno, Kara Pryke, Bryan Gall, Igor Landais, Daniel N Streblow, Klaus J Fruh, Victor R DeFilippis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sara BottoVaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, USA.
Jinu AbrahamVaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, USA.
Nobuyo MizunoVaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, USA.
Kara PrykeVaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, USA.
Bryan GallVaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, USA.
Igor LandaisVaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, USA.
Daniel N StreblowVaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, USA.
Klaus J FruhVaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, USA.
Victor R DeFilippisVaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, USA defilipp@ohsu.edu.
Oregon Health & Science University · US

Funding

The Burden of Chikungunya and Dengue Infection in KenyaU54AI081680 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI BEVAN, MICHAEL J · 2009 to 2013
$40.4M
Screening CoreU19AI109680 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MADDRY, JOSEPH A · 2014 to 2018
$34.9M
NIAID NIH HHS U19 AI109680NIAID NIH HHS U54 AI081680
6 · The paper itself

Abstract

Secretion of interleukin-1β (IL-1β) represents a fundamental innate immune response to microbial infection that, at the molecular level, occurs following activation of proteolytic caspases that cleave the immature protein into a secretable form. Human cytomegalovirus (HCMV) is the archetypal betaherpesvirus that is invariably capable of lifelong infection through the activity of numerous virally encoded immune evasion phenotypes. Innate immune pathways responsive to cytoplasmic double-stranded DNA (dsDNA) are known to be activated in response to contact between HCMV and host cells. Here, we used clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein 9 (Cas9) genome editing to demonstrate that the dsDNA receptor

Indexed as

Immune EvasionTranscription, GeneticCytomegalovirusDNA-Binding ProteinsHumansImmediate-Early ProteinsInflammasomesInterleukin-1betaProteolysisTHP-1 CellsTrans-ActivatorsAIM2 protein, humanDNA-Binding ProteinsIE2 protein, CytomegalovirusImmediate-Early ProteinsInflammasomesInterleukin-1betaTrans-ActivatorsAIM2cGAScytomegalovirusDNA sensorHCMVIE2IE86inflammasomeinnate immunityinterferonsSTING

Identifiers

PMID30755509
PMCPMC6372796
OpenAlexW2914921421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.