ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Neural Variability Limits Adolescent Skill Learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Neural competition between prefrontal and auditory cortex constrains novel sound strategy learning.Science advances · 2026Article
- Perceptual training selectively strengthens top-down signaling to sensory cortex.bioRxiv : the preprint server for biology · 2026Article
- Auditory perceptual expertise: Amplitude modulation rate discrimination near the threshold for detection.bioRxiv : the preprint server for biology · 2026Article
- Population-level encoding of task information is stronger in the adolescent compared to adult frontal cortex.Developmental cognitive neuroscience · 2026Article
- Article
- Neural Correlates of Perceptual Plasticity in the Auditory Midbrain and Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Orbitofrontal cortex modulates auditory cortical sensitivity and sound perception in Mongolian gerbils.Current biology : CB · 2024Article
- Developmental hearing loss-induced perceptual deficits are rescued by genetic restoration of cortical inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neural correlates of flexible sound perception in the auditory midbrain and thalamus.bioRxiv : the preprint server for biology · 2024Article
- Goal-directed learning in adolescence: neurocognitive development and contextual influences.Nature reviews. Neuroscience · 2024Review
- Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response.Translational psychiatry · 2023Article
- Organization of orbitofrontal-auditory pathways in the Mongolian gerbil.The Journal of comparative neurology · 2023Article
- Developmental hearing loss-induced perceptual deficits are rescued by cortical expression of GABAbioRxiv : the preprint server for biology · 2023Article
- Superior semicircular canal dehiscence and subsequent closure induces reversible impaired decision-making.Frontiers in neurology · 2023Article
- Auditory processing remains sensitive to environmental experience during adolescence in a rodent model.Nature communications · 2022Article
- Non-sensory Influences on Auditory Learning and Plasticity.Journal of the Association for Research in Otolaryngology : JARO · 2022Review
- Memory Specific to Temporal Features of Sound Is Formed by Cue-Selective Enhancements in Temporal Coding Enabled by Inhibition of an Epigenetic Regulator.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The relationship between pubertal hormones and brain plasticity: Implications for cognitive training in adolescence.Developmental cognitive neuroscience · 2020Review
- Stability in the Face of Change: Lifelong Experience-Dependent Plasticity in the Sensory Cortex.Frontiers in cellular neuroscience · 2020Article
- Preserving Inhibition during Developmental Hearing Loss Rescues Auditory Learning and Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Skill learning is fundamental to the acquisition of many complex behaviors that emerge during development. For example, years of practice give rise to perceptual improvements that contribute to mature speech and language skills. While fully honed learning skills might be thought to offer an advantage during the juvenile period, the ability to learn actually continues to develop through childhood and adolescence, suggesting that the neural mechanisms that support skill learning are slow to mature. To address this issue, we asked whether the rate and magnitude of perceptual learning varies as a function of age as male and female gerbils trained on an auditory task. Adolescents displayed a slower rate of perceptual learning compared with their young and mature counterparts. We recorded auditory cortical neuron activity from a subset of adolescent and adult gerbils as they underwent perceptual training. While training enhanced the sensitivity of most adult units, the sensitivity of many adolescent units remained unchanged, or even declined across training days. Therefore, the average rate of cortical improvement was significantly slower in adolescents compared with adults. Both smaller differences between sound-evoked response magnitudes and greater trial-to-trial response fluctuations contributed to the poorer sensitivity of individual adolescent neurons. Together, these findings suggest that elevated sensory neural variability limits adolescent skill learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.