ArticleBlood2019
PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.
Open access · bronzeAbstract read
In one paragraph
Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Optical genome mapping uncovers disease-defining variants in an adult T-lymphoblastic leukemia and impacts prognosis.Molecular cytogenetics · 2026Article
- Regulation of physical activity and energy expenditure through Phf6 in the medial preoptic area.Nature communications · 2026Article
- Regulation of stress susceptibility by chromatin-binding protein PHF6 in the pituitary intermediate lobe.Molecular psychiatry · 2026Article
- PHF6 interacts with the LMO2 complex in T-cell acute lymphoblastic leukemia.Haematologica · 2026Article
- Systematic Pan-Cancer Analysis Identifies PHF6 as an Immunological and Prognostic Biomarker.Diagnostics (Basel, Switzerland) · 2025Article
- Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness.Genes & development · 2025Article
- PHF6 and RUNX1 mutations cooperate to accelerate leukemogenesis.Translational oncology · 2025Article
- Deciphering the Complexities of Adult Human Steady State and Stress-Induced Hematopoiesis: Progress and Challenges.International journal of molecular sciences · 2025Review
- Article
- PHF6 suppresses self-renewal of leukemic stem cells in AML.Leukemia · 2024Article
- PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS.EMBO reports · 2024Article
- PHF6 loss reduces leukemia stem cell activity in an acute myeloid leukemia mouse model.Cancer cell international · 2024Article
- PHF6 suppresses self-renewal of leukemic stem cells in AML.bioRxiv : the preprint server for biology · 2024Article
- Börjeson-Forssman-Lehmann syndrome: delineating the clinical and allelic spectrum in 14 new families.European journal of human genetics : EJHG · 2023Article
- Article
- R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.iScience · 2023Article
- Epigenetic reversal of hematopoietic stem cell aging in Phf6-knockout mice.Nature aging · 2022Article
- Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Oncogenesis induced by combined Phf6 and Idh2 mutations through increased oncometabolites and impaired DNA repair.Oncogene · 2022Article
- Review
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Authors and funding
27 authors at 4 institutions in 1 country.
Helen M McRaeThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Alexandra L GarnhamThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Yifang HuThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Matthew T WitkowskiThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Mark A CorbettAdelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.
Mathew P DixonThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Rose E MayThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Bilal N SheikhThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
William ChiangThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.ORCID 0000-0002-3652-5963
Andrew J KuehThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Tan A NguyenThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Kevin ManThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Renee GlouryThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Brandon J AubreyThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Antonia PolicheniThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Ladina Di RagoThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Warren S AlexanderThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Daniel H D GrayThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Andreas StrasserThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Edwin D HawkinsThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Stephen WilcoxThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Jozef GéczAdelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.ORCID 0000-0002-7884-6861
Axel KalliesThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Matthew P McCormackAustralian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia; and.
Gordon K SmythThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.ORCID 0000-0001-9221-2892
Anne K VossThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Tim ThomasThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
The University of Melbourne · AUWalter and Eliza Hall Institute of Medical Research · AUThe University of Adelaide · AUAustralian Centre for HIV and Hepatitis Virology Research · AU
Funding
No grant is acknowledged in the PubMed record.
Abstract
Somatically acquired mutations in
Indexed as
AnimalsCarcinogenesisGene Expression RegulationHematopoietic Stem CellsHomeodomain ProteinsHumansLeukemiaMiceMice, KnockoutReceptors, InterferonRepressor ProteinsTumor Suppressor ProteinsHomeodomain ProteinsPhf6 protein, mouseReceptors, InterferonRepressor ProteinsTlx3 protein, mouseTumor Suppressor Proteins
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.