Evidence map›Paper›PMID 30755244›Full record

ArticleArthritis research & therapy2019

Deregulation of microRNA expression in monocytes and CD4

Olivier Fogel, Andreas Bugge Tinggaard, Maud Fagny, Nelly Sigrist, Elodie Roche, Laurence Leclere, Jean-François Deleuze, Frederic Batteux, Maxime Dougados, Corinne Miceli-Richard and 1 more

Open access · goldAbstract read
In one paragraph

Article in Arthritis research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  3. Reduced expression of miRNAs as potential biomarkers in axial spondyloarthritis.Revista da Associacao Medica Brasileira (1992) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Olivier FogelLaboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, 2 rue Gaston Crémieux, Evry, France.
Andreas Bugge TinggaardLaboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, 2 rue Gaston Crémieux, Evry, France.
Maud FagnyLaboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, 2 rue Gaston Crémieux, Evry, France.
Nelly SigristLaboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, 2 rue Gaston Crémieux, Evry, France.
Elodie RocheLaboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, 2 rue Gaston Crémieux, Evry, France.
Laurence LeclereLaboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, 2 rue Gaston Crémieux, Evry, France.
Jean-François DeleuzeLaboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, 2 rue Gaston Crémieux, Evry, France.
Frederic BatteuxDepartment of Immunology, Cochin Hospital, Paris, France.
Maxime DougadosDepartment of Rheumatology - Hôpital Cochin. Assistance Publique - Hôpitaux de Paris, Paris Descartes University, Paris, France.
Corinne Miceli-RichardDepartment of Rheumatology - Hôpital Cochin. Assistance Publique - Hôpitaux de Paris, Paris Descartes University, Paris, France.
Jörg TostLaboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, 2 rue Gaston Crémieux, Evry, France. tost@cng.fr.ORCID 0000-0002-2683-0817
Commissariat à l'Énergie Atomique et aux Énergies Alternatives · FRDélégation Paris 5 · FRAarhus University · DKHôpital Cochin · FR

Funding

Assistance Publique - Hôpitaux de Paris post accueilMSD avenir not applicablePfizer Passerelle WI213711UCB Sirius research
6 · The paper itself

Abstract

backgroundMicroRNAs (MiRs) play an important role in the pathogenesis of chronic inflammatory diseases. This study is the first to investigate miR expression profiles in purified CD4

methodsA total of 81 axSpA patients fulfilling the 2009 ASAS classification criteria, and 55 controls were recruited from October 2014 to July 2017. CD14

resultsWe found a major difference in miR expression patterns between T lymphocytes and monocytes regardless of the patient or control status. Comparing disease-specific differentially expressed miRs, 13 miRs were found consistently deregulated in CD14

conclusionsWe demonstrate a consistent deregulation of miRs in both monocytes and CD4

Indexed as

AdultAntirheumatic AgentsCD4-Positive T-LymphocytesCells, CulturedCohort StudiesFemaleGene Expression ProfilingHumansMaleMicroRNAsMiddle AgedMonocytesReverse Transcriptase Polymerase Chain ReactionSpineSpondylarthritisAntirheumatic AgentsMicroRNAsCD4+ T lymphocytesEpigeneticsMiRNAMonocytesSpondyloarthritis

Identifiers

PMID30755244
PMCPMC6373047
OpenAlexW2936400586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.