Evidence map›Paper›PMID 30755225›Full record

ArticleJournal of neuroinflammation2019

Annexin A1-derived peptide Ac

Alexandre D Gimenes, Bruna F D Andrade, José Victor P Pinotti, Sonia M Oliani, Orfa Y Galvis-Alonso, Cristiane D Gil

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 41 citations in OpenAlex.

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  13. Annexin Animal Models-From Fundamental Principles to Translational Research.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Alexandre D GimenesDepartment of Morphology and Genetics, Federal University of São Paulo (UNIFESP), São Paulo, SP, 04023-900, Brazil.
Bruna F D AndradeDepartment of Molecular Biology, São José do Rio Preto School of Medicine (FAMERP), São José do Rio Preto, SP, 15090-000, Brazil.
José Victor P PinottiDepartment of Morphology and Genetics, Federal University of São Paulo (UNIFESP), São Paulo, SP, 04023-900, Brazil.
Sonia M OlianiDepartment of Morphology and Genetics, Federal University of São Paulo (UNIFESP), São Paulo, SP, 04023-900, Brazil.
Orfa Y Galvis-AlonsoDepartment of Molecular Biology, São José do Rio Preto School of Medicine (FAMERP), São José do Rio Preto, SP, 15090-000, Brazil.
Cristiane D GilDepartment of Morphology and Genetics, Federal University of São Paulo (UNIFESP), São Paulo, SP, 04023-900, Brazil. cristiane.gil@unifesp.br.ORCID http://orcid.org/0000-0001-6979-4126
Faculdade de Medicina de São José do Rio Preto · BRUniversidade Federal de São Paulo · BRFundação de Apoio à Universidade Federal de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 308144/2014-7Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/02012-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/26872-5
6 · The paper itself

Abstract

backgroundThe inflammatory process has been described as a crucial mechanism in the pathophysiology of temporal lobe epilepsy. The anti-inflammatory protein annexin A1 (ANXA1) represents an interesting target in the regulation of neuroinflammation through the inhibition of leukocyte transmigration and the release of proinflammatory mediators. In this study, the role of the ANXA1-derived peptide Ac

methodsMale Wistar rats were divided into Naive, Sham, SE and SE+Ac

resultsPilocarpine induced generalised SE in all animals, causing neuronal damage, and systemic treatment with Ac

conclusionsThe data suggest a neuroprotective effect of Ac

Indexed as

AnimalsAnnexin A1AnticonvulsantsBlood-Brain BarrierCytokinesDiazepamDisease Models, AnimalGliosisHippocampusMaleMAP Kinase Signaling SystemMuscarinic AgonistsNerve DegenerationNerve Tissue ProteinsNeurogliaNeuronsAnnexin A1annexin A1 peptide (2-26)AnticonvulsantsCytokinesDiazepamlipoxin A(4) receptor, ratMuscarinic AgonistsNerve Tissue ProteinsNeuroprotective AgentsPeptidesPilocarpineReceptors, LipoxinCytokinesERKFpr2GliaHippocampusNeuroinflammation

Identifiers

PMID30755225
PMCPMC6371492
OpenAlexW2925129274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.