Evidence map›Paper›PMID 30755135›Full record

Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020

Longitudinal evaluation of surrogates of regional cerebral blood flow computed from dynamic amyloid PET imaging.

Murat Bilgel, Lori Beason-Held, Yang An, Yun Zhou, Dean F Wong, Susan M Resnick

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
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  6. Test-retest performance of [Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  7. Contribution of extracerebral tracer retention and partial volume effects to sex differences in Flortaucipir-PET signal.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  8. Longitudinal changes in Alzheimer's-related plasma biomarkers and brain amyloid.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  9. Article
  10. Measurement of Cerebral Perfusion Indices from the Early Phase of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  11. Longitudinal changes in Alzheimer's-related plasma biomarkers and brain amyloid.medRxiv : the preprint server for health sciences · 2023
    Article
  12. Precision estimates of relative and absolute cerebral blood flow in Alzheimer's disease and cognitively normal individuals.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  13. Article
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  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Murat BilgelLaboratory of Behavioral Neuroscience, National Institute on Aging (NIA), Baltimore, USA.ORCID 0000-0001-5042-7422
Lori Beason-HeldLaboratory of Behavioral Neuroscience, National Institute on Aging (NIA), Baltimore, USA.
Yang AnLaboratory of Behavioral Neuroscience, National Institute on Aging (NIA), Baltimore, USA.
Yun ZhouDepartment of Radiology and Radiological Science, Johns Hopkins University School (JHU) of Medicine, Baltimore, USA.
Dean F WongDepartment of Radiology and Radiological Science, Johns Hopkins University School (JHU) of Medicine, Baltimore, USA.
Susan M ResnickLaboratory of Behavioral Neuroscience, National Institute on Aging (NIA), Baltimore, USA.
National Institute on Aging · USJohns Hopkins University · US

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3M
Neuroimaging Predictors of Cognitive Decline, Impairment, and ResilienceZIAAG000191 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$26.4M
NIA NIH HHS P30 AG066507
6 · The paper itself

Abstract

Surrogates of neuronal activity, typically measured by regional cerebral blood flow (rCBF) or glucose metabolism, can be estimated from dynamic amyloid PET imaging. Using data for 149 participants (345 visits) from the Baltimore Longitudinal Study of Aging, we assessed whether the average of early amyloid frames (EA) and

Indexed as

Alzheimer DiseaseCerebrovascular CirculationPositron-Emission TomographyAgedAged, 80 and overAmyloidBlood Flow VelocityFemaleGlucoseHumansLongitudinal StudiesMaleAmyloidGlucoseAmyloidcerebral blood flowlongitudinalneurodegenerationneuronal activity

Identifiers

PMID30755135
PMCPMC7370613
OpenAlexW2912535613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.