ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2020
Higher EBV response is associated with more severe gray matter and lesion pathology in relapsing multiple sclerosis patients: A case-controlled magnetization transfer ratio study.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Adenotonsillectomy is associated with increased risk and disease activity in pediatric-onset multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Determinants of long-term paramagnetic rim lesion evolution in people with multiple sclerosis.Annals of clinical and translational neurology · 2025Article
- Greater humoral EBV response may be associated with choroid plexus inflammation in progressive MS.Journal of neurovirology · 2024Article
- EBNA-1 and VCA-p18 immunoglobulin markers link Epstein-Barr virus immune response and brain's myelin content to fatigue in a community-dwelling cohort.Brain, behavior, & immunity - health · 2024Article
- Serum Concentrations of Chemokines CCL20, CXCL8 and CXCL10 in Relapsing-Remitting Multiple Sclerosis and Their Association with Presence of Antibodies against Epstein-Barr Virus.International journal of molecular sciences · 2024Article
- Insights into the interplay between Epstein-Barr virus (EBV) and multiple sclerosis (MS): A state-of-the-art review and implications for vaccine development.Health science reports · 2024Article
- Teriflunomide and Epstein-Barr virus in a Spanish multiple sclerosis cohort:Frontiers in immunology · 2023Article
- Review
- Quantitative magnetization transfer imaging in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis.Brain communications · 2022Review
- Visual deficits and cognitive assessment of multiple sclerosis: confounder, correlate, or both?Journal of neurology · 2021Article
- Crosstalk of Microorganisms and Immune Responses in Autoimmune Neuroinflammation: A Focus on Regulatory T Cells.Frontiers in immunology · 2021Review
- EBV-specific CD8 T lymphocytes and B cells during glatiramer acetate therapy in patients with MS.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Serum Neurofilament Light Chain Levels are Associated with Lower Thalamic Perfusion in Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2020Article
- Article
- From Anti-EBV Immune Responses to the EBV Diseasome via Cross-reactivity.Global medical genetics · 2020Article
- Serum neurofilament light chain and optical coherence tomography measures in MS: A longitudinal study.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Review
- Cortical and Deep Gray Matter Perfusion Associations With Physical and Cognitive Performance in Multiple Sclerosis Patients.Frontiers in neurology · 2020Article
- Environmental Influencers, MicroRNA, and Multiple Sclerosis.Journal of central nervous system disease · 2020Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundEpstein-Barr virus (EBV) infection has been associated with higher clinical activity and risk of multiple sclerosis (MS).
objectiveTo evaluate associations between EBV-specific humoral response and magnetization transfer ratio (MTR)-derived measure in MS patients and healthy controls (HCs).
methodsThe study included 101 MS patients (69 relapsing-remitting multiple sclerosis (RRMS) and 32 secondary-progressive multiple sclerosis (SPMS)) and 41 HCs who underwent clinical, serological, and magnetic resonance imaging (MRI) investigations. MTR values of T1 or T2 lesion volume (LV), normal-appearing (NA) brain tissue (NABT), gray matter (NAGM), and white matter (NAWM) were obtained. Enzyme-linked immunosorbent assay was used to quantify EBV antibody levels. Partial correlations corrected for MRI strength were used, and Benjamini-Hochberg-adjusted
resultsMS patients had significantly higher anti-EBV nuclear antigen-1 (EBNA-1) titer when compared to HCs (107.9 U/mL vs 27.8 U/mL,
conclusionGreater EBV humoral response is associated with lower GM MTR changes and focal destructive lesion pathology in RRMS patients.
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