Evidence map›Paper›PMID 30755069›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020

Signal variance-based collateral index in DSC perfusion: A novel method to assess leptomeningeal collateralization in acute ischaemic stroke.

Alexander Seiler, Arne Lauer, Ralf Deichmann, Ulrike Nöth, Eva Herrmann, Joachim Berkefeld, Oliver C Singer, Waltraud Pfeilschifter, Johannes C Klein, Marlies Wagner

Open access · hybridAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  3. Cerebral small vessel disease does not impair leptomeningeal collateral supply in large-vessel occlusion - Results from quantitative collateral mapping with MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Alexander SeilerDepartment of Neurology, Goethe University Frankfurt, Frankfurt, Germany.
Arne LauerInstitute of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany.
Ralf DeichmannBrain Imaging Center, Goethe University Frankfurt, Frankfurt, Germany.
Ulrike NöthBrain Imaging Center, Goethe University Frankfurt, Frankfurt, Germany.
Eva HerrmannInstitute of Biostatistics and Mathematical Modelling, Goethe University Frankfurt, Frankfurt, Germany.
Joachim BerkefeldInstitute of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany.
Oliver C SingerDepartment of Neurology, Goethe University Frankfurt, Frankfurt, Germany.
Waltraud PfeilschifterDepartment of Neurology, Goethe University Frankfurt, Frankfurt, Germany.
Johannes C KleinWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Marlies WagnerInstitute of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany.
Goethe University Frankfurt · DEWellcome Centre for Integrative Neuroimaging · GB

Funding

Department of HealthWellcome Trust 203139/Z/16/Z
6 · The paper itself

Abstract

As a determinant of the progression rate of the ischaemic process in acute large-vessel stroke, the degree of collateralization is a strong predictor of the clinical outcome after reperfusion therapy and may influence clinical decision-making. Therefore, the assessment of leptomeningeal collateralization is of major importance. The purpose of this study was to develop and evaluate a quantitative and observer-independent method for assessing leptomeningeal collateralization in acute large-vessel stroke based on signal variance characteristics in T2*-weighted dynamic susceptibility contrast (DSC) perfusion-weighted MR imaging (PWI). Voxels representing leptomeningeal collateral vessels were extracted according to the magnitude of signal variance in the PWI raw data time series in 55 patients with proximal large-artery occlusion and an intra-individual collateral vessel index (CVI

Indexed as

Brain IschemiaCerebrovascular CirculationCollateral CirculationDatabases, FactualMagnetic Resonance ImagingMeningesStrokeAgedAged, 80 and overFemaleHumansMaleMiddle AgedAcute ischaemic strokecollateralsfunctional outcomemagnetic resonance imagingperfusion-weighted imaging

Identifiers

PMID30755069
PMCPMC7025396
OpenAlexW2912674880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.