Evidence map›Paper›PMID 30755057›Full record

ArticleJournal of the American Heart Association2019

Inositol 1,4,5-Trisphosphate Receptors in Endothelial Cells Play an Essential Role in Vasodilation and Blood Pressure Regulation.

Qingsong Lin, Lingyun Zhao, Ran Jing, Christa Trexler, Hong Wang, Yali Li, Huayuan Tang, Fang Huang, Fei Zhang, Xi Fang and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Deletion ofJournal of developmental biology · 2025
    Article
  5. Review
  6. Conditional deletion of IPJournal of gastroenterology · 2025
    Article
  7. Article
  8. Cracking the Endothelial Calcium (CaInternational journal of molecular sciences · 2023
    Review
  9. Article
  10. The Molecular Heterogeneity of Store-Operated CaInternational journal of molecular sciences · 2023
    Review
  11. Article
  12. IPiScience · 2022
    Article
  13. Article
  14. Article
  15. Reactive Oxygen Species and Endothelial CaInternational journal of molecular sciences · 2021
    Review
  16. Biomedicines · 2021
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Qingsong Lin1 Drug Discovery Center State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen China.
Lingyun Zhao1 Drug Discovery Center State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen China.
Ran Jing2 Department of Cardiology The Second Xiangya Hospital Central South University Changsha Hunan China.
Christa Trexler3 Department of Medicine School of Medicine University of California San Diego La Jolla CA.
Hong Wang1 Drug Discovery Center State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen China.
Yali Li1 Drug Discovery Center State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen China.
Huayuan Tang1 Drug Discovery Center State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen China.
Fang Huang1 Drug Discovery Center State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen China.
Fei Zhang1 Drug Discovery Center State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen China.
Xi Fang3 Department of Medicine School of Medicine University of California San Diego La Jolla CA.
Jie Liu4 Department of Pathophysiology School of Medicine Shenzhen University Shenzhen China.
Nan Jia5 Department of Cardiology The Eighth Affiliated Hospital Sun Yat-sen University Shenzhen China.
Ju Chen3 Department of Medicine School of Medicine University of California San Diego La Jolla CA.
Kunfu Ouyang1 Drug Discovery Center State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen China.
Peking University · CNUniversity of California, San Diego · USSecond Xiangya Hospital of Central South University · CNShenzhen University · CNSun Yat-sen University · CN

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
SCOR IN HEART FAILUREP50HL053773 · NHLBI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI CHIEN, KENNETH R · 1995 to 2004
$5.8M
Mediator complex in cardiac development and functionK99HL143210 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FANG, XI · 2018 to 2019
$314k
NHLBI NIH HHS K99 HL143210NHLBI NIH HHS P50 HL053773NIGMS NIH HHS K12 GM068524
6 · The paper itself

Abstract

Background Endothelial NO synthase plays a central role in regulating vasodilation and blood pressure. Intracellular Ca

Indexed as

AnimalsAorta, ThoracicBlood PressureCalciumDisease Models, AnimalEndothelial CellsEndothelium, VascularHypertensionImmunoblottingInositol 1,4,5-Trisphosphate ReceptorsMiceMice, Inbred C57BLMice, KnockoutMyographyVasodilationCalciumInositol 1,4,5-Trisphosphate ReceptorsItpr1 protein, mouseblood pressurecalciumcalcium signalingendothelial cellhypertension

Identifiers

PMID30755057
PMCPMC6405661
OpenAlexW2912332732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.