ArticleInternational journal of molecular sciences2019
Honey-Mediated Wound Healing: H₂O₂ Entry through AQP3 Determines Extracellular Ca
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 72 citations in OpenAlex.
- Nutriepigenetics in Skin Homeostasis: Molecular Mechanisms of Honey-Mediated Chromatin Remodeling in Non-Healing Ulcers.Biomolecules · 2026Review
- Botanical Origin-Dependent Phytochemical Profiles and Pharmaceutical Properties of Medical-Grade Honeys: Transdermal Delivery and Antibacterial Efficacy in a Wound Fluid Model.Molecules (Basel, Switzerland) · 2026Article
- Bioprospecting Honey-Derived Microorganisms for the Biological Control of Phytopathogens.Microorganisms · 2026Article
- Manuka honey as a natural remedy for diabetic foot ulcers: efficacy compared with silver-based dressing.Frontiers in pharmacology · 2026Article
- Honey and cancer: from traditional medicine to modern adjuvant therapy.Frontiers in oncology · 2026Review
- Rules of life at the interface of calcium signaling and mechanobiology.APL bioengineering · 2025Review
- Iron Chelation Reduces Intracellular Hydroxyl Radicals in Normal Human Dermal Fibroblasts Independently of Aging.Antioxidants (Basel, Switzerland) · 2025Article
- Natural Products for Improving Soft Tissue Healing: Mechanisms, Innovations, and Clinical Potential.Pharmaceutics · 2025Review
- Topical Application of Manuka Honey for the Treatment of Non-Healing Venous Leg Ulcers.Pharmaceuticals (Basel, Switzerland) · 2025Article
- The ion transport, GPCR, and RTK toolkit expression in the human cerebrovascular endothelial cell line, hCMEC/D3: an Omics perspective.Frontiers in physiology · 2025Article
- Correlation between Honey Parameters and Wound Healing Properties: The Case of Piedmont (Italy) Samples.Current pharmaceutical biotechnology · 2025Article
- Honey Bioactive Molecules: There Is a World Beyond the Sugars.Biotech (Basel (Switzerland)) · 2024Review
- Understanding the Anticancer Properties of Honey.International journal of molecular sciences · 2024Review
- Anti-Inflammatory and Wound Healing Properties of Different Honey Varieties from Romania and Correlations to Their Composition.Life (Basel, Switzerland) · 2024Article
- Wound Repair and CaCells · 2024Review
- Transient receptor potential ankyrin 1 (TRPA1) mediates reactive oxygen species-induced CaCell death discovery · 2023Article
- Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as a Sensor of Oxidative Stress in Cancer Cells.Cells · 2023Review
- Antibacterial and wound-healing action of Ulmo honey (Frontiers in veterinary science · 2023Article
- Intracellular CaFrontiers in physiology · 2023Review
- Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review.Frontiers in physiology · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Since Biblical times, honey has been utilized in "folk medicine", and in recent decades the positive qualities of honey have been re-discovered and are gaining acceptance. Scientific literature states that honey has been successfully utilized on infections not responding to classic antiseptic and antibiotic therapy, because of its intrinsic H₂O₂ production. In our study, we demonstrated the involvement of H₂O₂ as a main mediator of honey regenerative effects on an immortalized human keratinocyte cell line. We observed that this extracellularly released H₂O₂ could pass across the plasma membrane through a specific aquaporin (i.e., AQP3). Once in the cytoplasm H₂O₂, in turn, induces the entry of extracellular Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.