ArticleMolecules (Basel, Switzerland)2019
Formation and Investigation of Electrospun Eudragit E100/Oregano Mats.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Design of Polymeric Delivery Systems forFoods (Basel, Switzerland) · 2025Article
- Fabrication and Synthesis of Thiococlchicoside Loaded Matrix Type Transdermal Patch.Pharmaceutical nanotechnology · 2024Article
- Recent Progress of Electrospun Herbal Medicine Nanofibers.Biomolecules · 2023Review
- Cyclodextrin Derivatives as Promising Solubilizers to Enhance the Biological Activity of Rosmarinic Acid.Pharmaceutics · 2022Article
- Bioactive Properties of Nanofibres Based on Concentrated Collagen Hydrolysate Loaded with Thyme and Oregano Essential Oils.Materials (Basel, Switzerland) · 2020Article
- Electrospun Nanofibers for Label-Free Sensor Applications.Sensors (Basel, Switzerland) · 2019Review
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Authors and funding
6 authors.
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Abstract
An electrospun mat of Eudragit E100 (EE100) (a cationic copolymer based on dimethylaminoethyl methacrylate, butyl methacrylate, and methyl methacrylate) was used as a delivery system for oregano ethanolic extract (OEE). Oregano is a biologically active material which is widely used because of the antibacterial and antifungal activity. The oregano herb consists of phenolic compounds, the main of which are rosmarinic acid and from essential oil-carvacrol. Such a material could be an ideal candidate for oral drug systems. The influence of the EE100 concentration in the OEE on the structure of electrospun mats, encapsulation efficiency, dissolution profile, release kinetics and the stability of biologically active compounds was investigated. The concentration of the solution is a critical parameter for the structure and properties of electrospun mats. The diameter of electrospun fibers increased with the increase of EE100 concentration in the OEE. Electrospun mats obtained from 24% to 32% EE100 solutions showed high encapsulation efficiency, quick release and high stability of rosmarinic acid and carvacrol. Dissolution tests showed that 99% of carvacrol and 80% of rosmarinic acid were released after 10 min from electrospun nano-microfiber mats and capsules obtained from such formulations. The stability tests showed that physicochemical properties, dissolution profiles, and rosmarinic acid and carvacrol contents of the formulations were not significantly affected by storage.
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