Evidence map›Paper›PMID 30754632›Full record

ArticleMolecules (Basel, Switzerland)2019

Nanoformulation of a Novel Pyrano[2,3-c] Pyrazole Heterocyclic Compound AMDPC Exhibits Anti-Cancer Activity via Blocking the Cell Cycle through a

Xuanrong Sun, Longchao Zhang, Mengshi Gao, Xiangjie Que, Chenfeng Zhou, Dabu Zhu, Yue Cai

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Synthesis and Characterization of New Pyrano[2,3-Molecules (Basel, Switzerland) · 2023
    Article
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xuanrong SunCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. sunxr@zjut.edu.cn.ORCID 0000-0001-5414-9300
Longchao ZhangCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. 18809883089@163.com.
Mengshi GaoCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. igaomengshi@163.com.
Xiangjie QueCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. Que_xj@163.com.
Chenfeng ZhouCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. zcf19871025@126.com.
Dabu ZhuCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. 15757116042@163.com.
Yue CaiCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. chinacaiyue@163.com.

Funding

National Key R&D Program of China 2018YFC0311005National Natural Science Foundation of China No. 21506192Natural Science Foundation of Zhejiang Province No. LY16E030010
6 · The paper itself

Abstract

Pyrano[2,3-c]pyrazole derivatives have been reported as exerting various biological activities. One compound with potential anti-tumor activity was screened out by MTT assay from series of dihydropyrazopyrazole derivatives we had synthesized before using a one-pot, four-component reaction, and was named as 6-amino-4-(2-hydroxyphenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (hereinafter abbreviated as AMDPC). The IC

Indexed as

Antineoplastic AgentsBreast NeoplasmsCell CycleCell Line, TumorCell ProliferationCell SurvivalCyclin-Dependent Kinase Inhibitor p21FemaleGene Expression Regulation, NeoplasticHumansInhibitory Concentration 50MCF-7 CellsMicellesNanotechnologyPolyestersPolyethylene GlycolsAntineoplastic AgentsCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21MicellesPolyesterspolyethylene glycol-poly(lactide-co-glycolide)Polyethylene GlycolsPyrazolonesTP53 protein, humanTumor Suppressor Protein p53inhibition of cancer cell growthnanoformulationP21-related S phase and G2 phase arrestPyrano[2,3-c]pyrazole derivatives

Identifiers

PMID30754632
PMCPMC6384735

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.