Evidence map›Paper›PMID 30753832›Full record

ArticleDevelopmental cell2019

Invasion by Force: The C. elegans Anchor Cell Leads the Way.

Savvas Nikolaou, Laura M Machesky

Abstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Savvas NikolaouCRUK Beatson Institute and Institute of Cancer Sciences, University of Glasgow, G61 1BD, Glasgow, UK.
Laura M MacheskyCRUK Beatson Institute and Institute of Cancer Sciences, University of Glasgow, G61 1BD, Glasgow, UK. Electronic address: laura.machesky@glasgow.ac.uk.

Funding

Cancer Research UK 24452
6 · The paper itself

Abstract

How cells breach basement membrane barriers remains an area of active research. In this issue of Developmental Cell, Kelley et al. (2019) reveal that the C. elegans anchor cell uses physical force to breach basement membrane in the absence of matrix metalloproteases during its developmental invasion.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsActinsAdenosine TriphosphateAnimalsBasement MembraneMatrix MetalloproteinasesPolymerizationActinsAdenosine TriphosphateCaenorhabditis elegans ProteinsMatrix Metalloproteinases

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.