ArticleJournal of experimental botany2019
TaBT1, affecting starch synthesis and thousand kernel weight, underwent strong selection during wheat improvement.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 76 citations in OpenAlex.
- Quick creation and mapping of EMS-induced maize kernel mutants identifies classical gene ZmBT1 and novel gene ZmTOP6A.The plant genome · 2026Article
- The bHLH transcription factor PIL1 orchestrates starch synthesis in key cereal crops.Nature communications · 2025Article
- TaFT-D1 positively regulates grain weight by acting as a coactivator of TaFDL2 in wheat.Plant biotechnology journal · 2025Article
- The dynamic epigenetic atlas and its effects on instability of starch and seed storage protein quality traits in wheat (Frontiers in plant science · 2025Article
- Genetic Basis of Tillering Angle from Other Plants to Wheat: Current Progress and Future Perspectives.Plants (Basel, Switzerland) · 2024Review
- Identification and validation of two quantitative trait loci showing pleiotropic effect on multiple grain-related traits in bread wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Genomic-wide analysis reveals seven in absentia genes regulating grain development in wheat (Triticum aestivum L.).The plant genome · 2024Article
- Introgression of chromosome 5P from Agropyron cristatum enhances grain weight in a wheat background.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Genetic Analysis of Adaptive Traits in Spring Wheat in Northeast China.Life (Basel, Switzerland) · 2024Article
- Understanding grain development in the Poaceae family by comparing conserved and distinctive pathways through omics studies in wheat and maize.Frontiers in plant science · 2024Review
- An intron-located single nucleotide variation of TaGS5-3D is related to wheat grain size through accumulating intron retention transcripts.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- A promising QTL QSns.sau-MC-3D.1 likely superior to WAPO1 for the number of spikelets per spike of wheat shows no adverse effects on yield-related traits.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Gene expression profile of the developing endosperm in durum wheat provides insight into starch biosynthesis.BMC plant biology · 2023Article
- TaTPP-7A positively feedback regulates grain filling and wheat grain yield through T6P-SnRK1 signalling pathway and sugar-ABA interaction.Plant biotechnology journal · 2023Article
- Wheat NAC-A18 regulates grain starch and storage proteins synthesis and affects grain weight.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Chromatin accessibility landscapes revealed the subgenome-divergent regulation networks during wheat grain development.aBIOTECH · 2023Article
- The auxin response factor TaARF15-A1 negatively regulates senescence in common wheat (Triticum aestivum L.).Plant physiology · 2023Article
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- Genetic dissection of major QTL for grain number per spike on chromosomes 5A and 6A in bread wheat (Frontiers in plant science · 2023Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BRITTLE1 (BT1), responsible for unidirectional transmembrane transport of ADP-glucose, plays a pivotal role in starch synthesis of cereal grain. In this study, we isolated three TaBT1 homoeologous genes located on chromosomes 6A, 6B, and 6D in common wheat. TaBT1 was mainly expressed in developing grains, and knockdown of TaBT1 in common wheat produced a decrease in grain size, thousand kernel weight (TKW), and grain total starch content. High diversity was detected at the TaBT1-6B locus, with 24 polymorphic sites forming three haplotypes (Hap1, Hap2, and Hap3). Association analysis revealed that Hap1 and Hap2 were preferred haplotypes in modern breeding, for their significant correlations with higher TKW. Furthermore, β-glucuronidase (GUS) staining and enzyme activity assays in developing grains of transgenic rice with exogenous promoters indicated that the promoters of Hap1 and Hap2 showed stronger driving activity than that of Hap3. Evolutionary analysis revealed that BT1 underwent strong selection during wheat polyploidization. In addition, the frequency distribution of TaBT1-6B haplotypes revealed that Hap1 and Hap2 were preferred in global modern wheat cultivars. Our findings suggest that TaBT1 has an important effect on starch synthesis and TKW, and provide two valuable molecular markers for marker assisted selection (MAS) in wheat high-yield breeding.
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