ArticleSleep2019
Pulse transit time in pregnancy: a new way to diagnose and classify sleep disordered breathing?
Article in Sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Treatment of obstructive sleep apnea in high risk pregnancy: a multicenter randomized controlled trial.Respiratory research · 2023Trial
- Heart rate and vascular responses to spontaneous arousals following experimental sleep restriction.American journal of physiology. Heart and circulatory physiology · 2026Article
- Delivery outcomes as a result of snoring as determined by standard sleep surveys.Obstetric medicine · 2022Article
- Evaluating changes in pulse transit time drop index in patients with obstructive sleep apnea before and during CPAP therapy.The clinical respiratory journal · 2022Article
- Can Diagnostic Specificity and Phenotyping Aid in Evaluating Cardiometabolic Risk of Maternal Sleep-disordered Breathing?American journal of respiratory and critical care medicine · 2022Article
- Association between sleep disordered breathing in early pregnancy and glucose metabolism.Sleep · 2022Article
- Impact of nasal dilator strips on measures of sleep-disordered breathing in pregnancy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- The intersection of women's health, lung health, and disease.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Obstructive sleep apnea in pregnancy: 1 sleep study may not be enough in high-risk women.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Sleep Disordered Breathing Measures in Early Pregnancy Are Associated with Depressive Symptoms in Late Pregnancy.Diagnostics (Basel, Switzerland) · 2021Article
- Sleep Disordered Breathing, a Novel, Modifiable Risk Factor for Hypertensive Disorders of Pregnancy.Current hypertension reports · 2020Review
- Cardiovascular Disease in Women Across the Lifespan: The Importance of Sleep.Journal of women's health (2002) · 2020Article
- Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
STUDY
objectivesThere are significant discrepancies between the prevalence of snoring and that of objectively defined sleep disordered breathing among pregnant women, suggesting subtle airflow limitations that may not be captured by conventional scoring. This study examined the performance of pulse transit time, an indirect measure of arterial stiffness and sympathetic activation, in pregnancy.
methodsPregnant women with obesity and snoring and a group of controls without symptoms of sleep disordered breathing were recruited in the first trimester. Women underwent a level III in-laboratory sleep monitoring study including an electrocardiogram and pulse oximetry, and pulse transit time was measured. Sleep disordered breathing was defined as an apnea-hypopnea index at least five events per hour of sleep. Statistical analysis was performed using Spearman correlation, Fisher's exact t-test, and univariate analysis.
resultsOf the 222 women, 38 met criteria for sleep disordered breathing. Pulse transit time drops were very prevalent (95% of participants with snoring had > 5 drops per hour). Median apnea-hypopnea index was 0.7 (interquartile range [IQR]: 2.6) events per hour whereas median pulse transit time drop index was 20.70 (IQR: 35.90) events per hour. Pulse transit time index was significantly higher in snorers with apnea-hypopnea index less than five events per hours and participants with apnea-hypopnea index greater than five events per hour compared to controls. Examination of random epochs with pulse transit time drops showed that 95% of pulse transit time drops were associated with airflow limitation.
conclusionsPulse transit time ascertains frequent events of sympathetic activation in at-risk women with and without sleep disordered breathing beyond conventional apneas and hypopneas. Pulse transit time may be an important addition to the identification of clinically significant sleep disordered breathing in pregnant women, and may identify more sleep disordered breathing than apnea-hypopnea index.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.