Evidence map›Paper›PMID 30753625›Full record

Trial reportThe Journal of nutrition2019

Maternal-Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Does Not Affect Child Blood Pressure at 4-6 Y in Ghana: Follow-up of a Randomized Trial.

Sika M Kumordzie, Seth Adu-Afarwuah, Rebecca R Young, Brietta M Oaks, Solace M Tamakloe, Maku E Ocansey, Harriet Okronipa, Elizabeth L Prado, Kathryn G Dewey

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00970866 (Efficacy of Lipid-based Nutrient Supplements), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00970866 nacompletednot on this map

Efficacy of Lipid-based Nutrient Supplements (LNS) for Pregnant and Lactating Women and Their Infants

TypeinterventionalSponsorUniversity of California, DavisRan2009 to 2017Enrolled3,499ConditionsAnemia, Malnutrition, StuntingArmsIron and Folic Acid (IFA), Multiple Micronutrient (MMN) group, Lipid-based Nutrient Supplements (LNS) group
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sika M KumordzieProgram in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, CA.
Seth Adu-AfarwuahDepartment of Nutrition and Food Science, University of Ghana, Legon, Ghana.
Rebecca R YoungProgram in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, CA.
Brietta M OaksProgram in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, CA.
Solace M TamakloeDepartment of Nutrition and Food Science, University of Ghana, Legon, Ghana.
Maku E OcanseyProgram in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, CA.
Harriet OkronipaProgram in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, CA.
Elizabeth L PradoProgram in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, CA.
Kathryn G DeweyProgram in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, CA.
University of California, Davis · USUniversity of Ghana · GHUniversity of Rhode Island · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the International Lipid-Based Nutrient Supplements (iLiNS)-DYAD-Ghana trial, prenatal small-quantity lipid-based nutrient supplements (LNSs) had a positive effect on birth weight. Birth weight may be inversely related to blood pressure (BP) later in life.

objectivesWe examined the effect of the intervention on BP at 4-6 y of age, and maternal and child factors related to BP.

methodsThe iLiNS-DYAD-Ghana study was a partially double-blind, randomized controlled trial which assigned women (n = 1320) ≤20 weeks of gestation to daily supplementation with: 1) iron and folic acid during pregnancy and 200 mg Ca for 6 mo postpartum , 2) multiple micronutrients during pregnancy and postpartum, or 3) LNSs during pregnancy and postpartum plus LNSs for infants from 6 to 18 mo of age. At 4-6 y of age (n = 858, 70% of live births), we compared BP, a secondary outcome, between non-LNS and LNS groups and examined whether BP was related to several factors including maternal BP, child weight-for-age z score (WAZ), and physical activity.

resultsNon-LNS and LNS groups did not differ in systolic (99.2 ± 0.4 compared with 98.5 ± 0.6 mm Hg; P = 0.317) or diastolic (60.1 ± 0.3 compared with 60.0 ± 0.4 mm Hg; P = 0.805) BP, or prevalence of high BP (systolic or diastolic BP ≥90th percentile of the US National Heart, Lung, and Blood Institute reference: 31% compared with 28%; P = 0.251). BP at 4-6 y of age was positively related to birth weight; this relation was largely mediated through concurrent WAZ in a path model. Concurrent WAZ and maternal BP were the factors most strongly related to child BP.

conclusionsDespite greater birth weight in the LNS group, there was no intervention group difference in BP at 4-6 y. In this preschool population at high risk of adult hypertension based on BP at 4-6 y, high maternal BP and child WAZ were key factors related to BP. This trial was registered at clinicaltrials.gov as NCT00970866.

Indexed as

Dietary SupplementsAdultBlood PressureChildChild, PreschoolFemaleFollow-Up StudiesGhanaHumansInfantLipidsYoung AdultLipidsblood pressureGhanaian children; prenatal; infant nutritionlipid-based nutrient supplementssupplementation

Identifiers

PMID30753625
PMCPMC6398380
OpenAlexW2914316479

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.