ArticleThe Journal of antimicrobial chemotherapy2019
CMY-1/MOX-family AmpC β-lactamases MOX-1, MOX-2 and MOX-9 were mobilized independently from three Aeromonas species.
Article in The Journal of antimicrobial chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Metagenomic Profiling of Soil Microbiomes and Resistomes in Arid Ecosystems of Kuwait.Antibiotics (Basel, Switzerland) · 2026Article
- A novel self-transmissible mega plasmid from extensively drug-resistantCurrent research in microbial sciences · 2026Article
- Unraveling Genomic and Pathogenic Features ofAnimals : an open access journal from MDPI · 2025Article
- Evaluation of an expanded antibiotic resistance gene panel on prediction of antimicrobial susceptibility results for Gram-negative bacteria in blood cultures.Journal of clinical microbiology · 2024Article
- Identification and specificity validation of unique and antimicrobial resistance genes to trace suspected pathogenic AMR bacteria and to monitor the development of AMR in non-AMR strains in the environment and clinical settings.Saudi journal of biological sciences · 2023Article
- The Impact of Cefuroxime Susceptibility onMicroorganisms · 2023Article
- Characterization of Third Generation Cephalosporin- and Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Whole genome sequence analysis ofFrontiers in microbiology · 2023Article
- Class C β-Lactamases: Molecular Characteristics.Clinical microbiology reviews · 2022Review
- Molecular and Kinetic Characterization of MOX-9, a Plasmid-Mediated Enzyme Representative of a Novel Sublineage of MOX-Type Class C β-Lactamases.Antimicrobial agents and chemotherapy · 2022Article
- Characterization of virulence and antimicrobial resistance genes ofFrontiers in microbiology · 2022Article
- Taxonomic Identification of Different Species of the Genus Aeromonas by Whole-Genome Sequencing and Use of Their Species-Specific β-Lactamases as Phylogenetic Markers.Antibiotics (Basel, Switzerland) · 2021Article
- A framework for identifying the recent origins of mobile antibiotic resistance genes.Communications biology · 2021Article
- Molecular and Functional Characterization of a Novel Plasmid-BorneInfection and drug resistance · 2021Article
- Marine Plastics from Norwegian West Coast Carry Potentially Virulent Fish Pathogens and Opportunistic Human Pathogens Harboring New Variants of Antibiotic Resistance Genes.Microorganisms · 2020Article
- A comprehensive survey of integron-associated genes present in metagenomes.BMC genomics · 2020Article
- Characterization of Beta-Lactamases in Bloodstream-InfectionFrontiers in microbiology · 2019Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the origin of CMY-1/MOX-family β-lactamases.
methodsPublicly available genome assemblies were screened for CMY-1/MOX genes. The loci of CMY-1/MOX genes were compared with respect to synteny and nucleotide identity, and subjected to phylogenetic analysis.
resultsThe chromosomal ampC genes of several Aeromonas species were highly similar to known mobile CMY-1/MOX variants. Annotation and sequence comparison revealed nucleotide identities >98% and conserved syntenies between MOX-1-, MOX-2- and MOX-9-associated mobile sequences and the chromosomal Aeromonas sanarellii, Aeromonas caviae and Aeromonas media ampC loci. Furthermore, the phylogenetic analysis showed that MOX-1, MOX-2 and MOX-9 formed three distinct monophyletic groups with the chromosomal ampC genes of A. sanarellii, A. caviae and A. media, respectively.
conclusionsOur findings show that three CMY-1/MOX-family β-lactamases were mobilized independently from three Aeromonas species and hence shine new light on the evolution and emergence of mobile antibiotic resistance genes.
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