ArticleThe Journal of antimicrobial chemotherapy2019
Dynamics of faecal shedding of ESBL- or AmpC-producing Escherichia coli on dairy farms.
Article in The Journal of antimicrobial chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Occurrence of ESBL-E. coli in feces of dairy calves and nipples of teat buckets for calves before and after automatic cleaning in two dairy farms.Scientific reports · 2026Article
- Longitudinal study on the genetic diversity of extended-spectrum cephalosporin resistantFrontiers in microbiology · 2025Article
- Gut colonization by extended-spectrum β-lactamase-producing Escherichia coli in dairy herd in Brazil: successful dissemination of a One Health clone.Veterinary research communications · 2024Article
- Colostrum as a source of ESBL-Escherichia coli in feces of newborn calves.Scientific reports · 2024Article
- Whole-genome sequencing-based antimicrobial resistance and shedding dynamics ofMicrobiology spectrum · 2024Article
- Extended spectrum cephalosporin (ESC) resistantScience in One Health · 2024Article
- The fly route of extended-spectrum-β-lactamase-producingFrontiers in antibiotics · 2024Article
- Standardization and evaluation of indicators for quantifying antimicrobial use on U.S. dairy farms.Frontiers in antibiotics · 2023Article
- Characterization of cephalosporin and fluoroquinolone resistant Enterobacterales from Irish farm waste by whole genome sequencing.Frontiers in microbiology · 2023Article
- Potential of ESBL-producing Escherichia coli selection in bovine feces after intramammary administration of first generation cephalosporins using in vitro experiments.Scientific reports · 2022Article
- Extended-Spectrum ß-Lactamase-ProducingMicroorganisms · 2022Article
- Within-farm dynamics of ESBL-producingFrontiers in microbiology · 2022Article
- Prevalence and distribution of extended-spectrum β-lactamase and AmpC-producingFrontiers in microbiology · 2022Article
- Interplay between Bacterial Clones and Plasmids in the Spread of Antibiotic Resistance Genes in the Gut: Lessons from a Temporal Study in Veal Calves.Applied and environmental microbiology · 2021Article
- ESBL/pAmpC-producing Escherichia coli and Klebsiella pneumoniae carriage among veterinary healthcare workers in the Netherlands.Antimicrobial resistance and infection control · 2021Article
- Prevalence and Risk Factors for ESBL/AmpC-Microorganisms · 2021Article
- Role played by the environment in the emergence and spread of antimicrobial resistance (AMR) through the food chain.EFSA journal. European Food Safety Authority · 2021Article
- Drivers of ESBL-producingOne health (Amsterdam, Netherlands) · 2021Article
- Antibiotic Resistance Profiles and Molecular Characteristics of Extended-Spectrum Beta-Lactamase (ESBL)-ProducingFrontiers in microbiology · 2021Article
- Prevalence of Antimicrobial Resistance and Characteristics ofFrontiers in veterinary science · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore the dynamics of faecal ESBL/AmpC shedding in dairy cattle and farmers, a study was conducted to examine changes in shedding by individual animals, as well as environmental exposure, and to study the association between antimicrobial use (AMU) and ESBL/AmpC shedding.
methodsThe study comprised a cross-sectional survey of 20 farms and a 1 year follow-up of 10 farms. Faecal samples were cultured by both direct inoculation on MacConkey agar + 1 mg/L cefotaxime (MC+) and enrichment in LB-broth + 1 mg/L cefotaxime with subsequent inoculation on MC+. Dust samples were collected using electrostatic dustfall collectors (EDCs). Human faecal samples were collected by the farmers. Presence of ESBL/AmpC genes was screened for by PCR and sequencing. Using mixed effects logistic regression, ORs were determined and population-attributable fractions (PAFs) calculated subsequently.
resultsIn Phase 1, 8/20 farms were positive for ESBL/AmpC and, with 2 negative farms, were selected for Phase 2. Transient shedding of dominant allele variants was observed in the animals. EDCs and human faecal samples did not reflect what was observed in the animals. AMU was related to shedding of ESBLs in the next sampling moment [OR 14.6 (95% CI 3.0-80.0)] and the PAF of AMU was 0.36 (95% CI 0.08-0.77). Calves fed with colostrum from cows on dry-off therapy was not a risk factor [OR 1.7 (95% CI 0.7-4.9, P = 0.28)].
conclusionsThe presence of ESBL/AmpC could only be partly explained by AMU. No link was shown between shedding in cattle and humans or the environment. Interventions should focus on prevention of introduction.
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