ReviewEuropean heart journal2019
Mechanisms linking preterm birth to onset of cardiovascular disease later in adulthood.
Review in European heart journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis.European heart journal · 2023Pooled it
- Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study.BMC medicine · 2023Pooled it
- From Neonatal History to Adult Cardiovascular Risk: Preterm Birth as a Lifelong Risk Enhancer.Medical sciences (Basel, Switzerland) · 2026Review
- Quantitative measures of autonomic cardiorespiratory maturation in preterm infants are associated with brain volumes at term age.Early human development · 2026Article
- Long-Term Consequences of Preterm Birth: A Lifespan Perspective.Developmental neuroscience · 2026Review
- Multiscale computational modeling of the cardiopulmonary consequences of postnatal hyperoxia with implications for preterm-born children.Biomechanics and modeling in mechanobiology · 2026Article
- ABO Incongruency Increases Risk for Necrotizing Enterocolitis in Preterm Neonates.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2026Article
- Caspase-1 inhibition mitigates neonatal hyperoxia-induced vascular and cardiopulmonary inflammation in neonatal rats.Clinical science (London, England : 1979) · 2025Article
- Cardiac autonomic function in adults born preterm with very low birth weight in mid-adulthood-A two-country birth cohort study.Physiological reports · 2025Article
- Preterm Birth and Risk of Health Service Use, Morbidity, and Medication Needs at 5 Years.JAMA pediatrics · 2025Article
- Integrated Metagenomic and Metabolomic Analyses Reveal a Microbiota-Metabolite Axis Associated with Gallstone Pathogenesis.Metabolites · 2025Article
- A Pilot Multi-Omics Approach Unveils Strong Immune Activation in the First Ten Days of Life in Extremely Preterm Infants.Metabolites · 2025Article
- Multiscale Computational Modeling of the Cardiopulmonary Consequences of Postnatal Hyperoxia with Implications for Preterm Born Children.bioRxiv : the preprint server for biology · 2025Article
- Neonatal Urine Metabolic Signature Reflects Multisystemic Adaptations Linked to Preterm Birth.International journal of molecular sciences · 2025Article
- Expanding diversity in developmental profiles of very-low-birth-weight infants during 6 years after birth.Scientific reports · 2025Article
- Fertility and abortion: A population-based comparison between women with cancer and those in childbearing age.Tumori · 2025Article
- Early-life gut microbiome development and its potential long-term impact on health outcomes.Microbiome research reports · 2025Review
- Transition phase of nutrition-optimizing nutrient administration.Frontiers in pediatrics · 2025Review
- Epigenetic signature of very low birth weight in young adult life.Pediatric research · 2025Article
- Cardiovascular responses to heat and cold exposure are altered by preterm birth in guinea pigs.Physiological reports · 2024Article
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
Abstract
Cardiovascular disease (CVD) rates in adulthood are high in premature infants; unfortunately, the underlying mechanisms are not well defined. In this review, we discuss potential pathways that could lead to CVD in premature babies. Studies show intense oxidant stress and inflammation at tissue levels in these neonates. Alterations in lipid profile, foetal epigenomics, and gut microbiota in these infants may also underlie the development of CVD. Recently, probiotic bacteria, such as the mucin-degrading bacterium Akkermansia muciniphila have been shown to reduce inflammation and prevent heart disease in animal models. All this information might enable scientists and clinicians to target pathways to act early to curtail the adverse effects of prematurity on the cardiovascular system. This could lead to primary and secondary prevention of CVD and improve survival among preterm neonates later in adult life.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.