SynthesisClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019
Birth Cohort Studies Assessing Norovirus Infection and Immunity in Young Children: A Review.
Synthesis in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Production and Clinical Evaluation of Norwalk GI.1 Virus Lot 001-09NV in Norovirus Vaccine Development.The Journal of infectious diseases · 2020Trial
- Global trends in norovirus genotype distribution among medically attended children with acute gastroenteritis, 2020-2025.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2026Article
- Enteric Viral Pathogens in Infants in the United States: 2017-2020.Pediatrics · 2026Article
- Article
- Viral co-infections in pediatric acute gastroenteritis: epidemiology of rotavirus, norovirus, adenovirus, and astrovirus in Tehran, Iran (2021-2022).BMC infectious diseases · 2025Article
- Norovirus-associated diarrhea and asymptomatic infection in children aged under 4 years: a community-cohort study in the Philippines.IJID regions · 2025Article
- Metabolic immaturity and breastmilk bile acid metabolites are central determinants of heightened newborn vulnerability to norovirus diarrhea.Cell host & microbe · 2024Article
- Prevalence, Clinical Features, and Genotypes of Norovirus-Associated Diarrhea in Wuxi, China, 2013-2020.The American journal of tropical medicine and hygiene · 2024Article
- The Impact of Norovirus on Children and Adolescents: Implications for Ongoing Vaccine Development.Current pediatrics reports · 2024Review
- Vaccine value profile for norovirus.Vaccine · 2023Article
- Infection of neonatal mice with the murine norovirus strain WU23 is a robust model to study norovirus pathogenesis.Lab animal · 2023Article
- Age-associated features of norovirus infection analysed in mice.Nature microbiology · 2023Article
- Norovirus Disease Among Children <5 Years in 3 Sub-Saharan African Countries: Findings From the Vaccine Impact on Diarrhea in Africa (VIDA) Study, 2015-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants.Virology journal · 2023Article
- Molecular characteristics of norovirus in sporadic and outbreak cases of acute gastroenteritis and in sewage in Sichuan, China.Virology journal · 2022Article
- Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children.Journal of the Pediatric Infectious Diseases Society · 2022Article
- Norovirus Infection in Young Nicaraguan Children Induces Durable and Genotype-Specific Antibody Immunity.Viruses · 2022Article
- Profiling of humoral immune responses to norovirus in children across Europe.Scientific reports · 2022Article
- Epidemiology, Clinical Features, and Unusual Complications of Norovirus Infection in Taiwan: What We Know after Rotavirus Vaccines.Pathogens (Basel, Switzerland) · 2022Review
- 52-year follow-up of a birth cohort reveals a high pneumonia incidence among young men.ERJ open research · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Globally, noroviruses are among the foremost causes of acute diarrheal disease, yet there are many unanswered questions on norovirus immunity, particularly following natural infection in young children during the first 2 years of life when the disease burden is highest. We conducted a literature review on birth cohort studies assessing norovirus infections in children from birth to early childhood. Data on infection, immunity, and risk factors are summarized from 10 community-based birth cohort studies conducted in low- and middle-income countries. Up to 90% of children experienced atleast one norovirus infection and up to 70% experienced norovirus-associated diarrhea, most often affecting children 6 months of age and older. Data from these studies help to fill critical knowledge gaps for vaccine development, yet study design and methodological differences limit comparison between studies, particularly for immunity and risk factors for disease. Considerations for conducting future birth cohort studies on norovirus are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.