ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019
Clinical and Microbiologic Variables Predictive of Orthopedic Complications Following Staphylococcus aureus Acute Hematogenous Osteoarticular Infections in Children.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Short- versus long-course of antimicrobial treatment in pediatric population with acute osteoarticular infections: a systematic review and meta-analysis.European journal of pediatrics · 2026Pooled it
- Pediatric calcaneal osteomyelitis: an analysis of literature-reported 128 cases.BMC infectious diseases · 2024Pooled it
- Pooled it
- The PVL threat: A multicenter, single-cohort retrospective study of Panton-Valentine leukocidin staphylococcal infections in critically ill children.European journal of pediatrics · 2026Article
- How Should Bacteriological Sampling Be Stratified in Paediatric Septic Arthritis? A Narrative Review with a Proposed Risk-Stratified Framework.Antibiotics (Basel, Switzerland) · 2026Review
- Clinical Characteristics and Outcomes of Culture-positive Versus Culture-negative Bone and Joint Infections in Pediatric Patients: A 10-Year Multicenter Study From Hungary.The Pediatric infectious disease journal · 2026Observational
- Admission albumin and C-reactive protein-to-lymphocyte ratio are associated with MRI-defined abscess in children with acute hematogenous osteomyelitis: a two-center retrospective study.Frontiers in cellular and infection microbiology · 2026Observational
- Clinical characteristics and risk factors for pathological fractures in children with Staphylococcus aureus osteoarticular infections: a retrospective cohort study.Italian journal of pediatrics · 2025Article
- Clinical features and sequelae of pediatric osteomyelitis following surgical treatment: a 10-year retrospective study.BMC infectious diseases · 2025Article
- Clinical characteristics and risk factors for poor prognosis in children with complicated acute hematogenous osteomyelitis treated with vaccum sealing drainage.BMC musculoskeletal disorders · 2025Article
- Clinical characteristics of children with disseminatedFuture microbiology · 2025Article
- Management of pathologic fracture of long bones as a complication of acute osteomyelitis: a challenging task for orthopedic surgeons.BMC musculoskeletal disorders · 2025Article
- Article
- Analysis of clinical characteristics and risk factors for Staphylococcus aureus disseminated infection secondary to acute osteoarticular infections in children.Italian journal of pediatrics · 2025Article
- [Arthritis and osteomyelitis in childhood and adolescence-Bacterial and nonbacterial].Zeitschrift fur Rheumatologie · 2025Review
- Association of Antibiotic Route and Outcomes in Children with Methicillin-Resistant Staphylococcus aureus Bacteremic Osteomyelitis.Infectious diseases and therapy · 2025Article
- The correlation between serum calcium levels and prognosis in patients with severe acute osteomyelitis.Frontiers in immunology · 2024Article
- A transformer-based deep learning model for identifying the occurrence of acute hematogenous osteomyelitis and predicting blood culture results.Frontiers in microbiology · 2024Article
- Defining Variability in Evaluation and Management of Children with Chronic Osteomyelitis.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Diagnosis and treatment of chronic osteomyelitis based on nanomaterials.World journal of orthopedics · 2023Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundStaphylococcus aureus is the most common cause of acute hematogenous osteoarticular infections (AHOAIs) in children. The risk factors for the development of orthopedic complications (OC) after AHOAI are poorly understood. We sought to describe clinical and microbiologic variables present on the index admission that may predict OC in S. aureus AHOAI.
methodsStaphylococcus aureus AHOAI cases were identified from 2011-2017 at Texas Children's Hospital and reviewed for the development of OC. OC included chronic osteomyelitis, growth arrest, avascular necrosis, chronic dislocation, and pathologic fracture. All S. aureus isolates were characterized by pulsed-field gel electrophoresis and agr group.
resultsA total of 286 cases were examined of which 27 patients (9.4%) developed OC. Patients who developed OC more often had infection with an agr group III organism (P = .04), bacteremia (P = .04), delayed source control (P < .001), ≥2 surgical procedures (P < .001), intensive care unit admission (P = .09), and fever >4 days after admission (P = .008). There was no association with OC and patient age, methicillin resistance, or choice/route of antibiotics. In multivariable analyses of OC, infection with agr group III S. aureus, prolonged fever, and delayed source control remained statistically significant.
conclusionsOC develop following S. aureus AHOAI in 9.4% of cases. Although the development of OC is likely multifactorial, agr group III organisms, prolonged fever, and delayed source control are independently associated with OC. Moreover, early aggressive surgical source control may be beneficial in children with S. aureus AHOAI.
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