ArticlePloS one2019
Frequency-resolved analysis of coherent oscillations of local cerebral blood volume, measured with near-infrared spectroscopy, and systemic arterial pressure in healthy human subjects.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 19 citations in OpenAlex.
- Cross-sectional and longitudinal analysis of prefrontal intermittent theta-burst stimulation-evoked hemodynamic responses in major depressive disorder.Translational psychiatry · 2026Article
- Dynamic Windkessel autoregulation for optical hemodynamic imaging: quantifying microcirculation, oxygen diffusion, and vascular autoregulation from low-frequency hemodynamic oscillations.Biomedical optics express · 2026Article
- Comparative analysis of the effects of the computer-based and paper-based trail making tests on oxygenation in the prefrontal cortex.BMC neuroscience · 2024Article
- Effects of high-intensity interval training in a cold environment on arterial stiffness and cerebral hemodynamics in sedentary Chinese college female students post-COVID-19.Frontiers in neurology · 2024Article
- Spatial-Temporal Oxygenation Mapping Using a Near-Infrared Optical Scanner: Towards Peripheral Vascular Imaging.Annals of biomedical engineering · 2023Article
- Human-in-the-Loop Optimization of Transcranial Electrical Stimulation at the Point of Care: A Computational Perspective.Brain sciences · 2022Article
- Article
- Noninvasive Optical Measurements of Dynamic Cerebral Autoregulation by Inducing Oscillatory Cerebral Hemodynamics.Frontiers in neurology · 2021Article
- Signal regression in frequency-domain diffuse optical tomography to remove superficial signal contamination.Neurophotonics · 2021Article
- Diffuse optical assessment of cerebral-autoregulation in older adults stratified by cerebrovascular risk.Journal of biophotonics · 2020Article
- Phase dual-slopes in frequency-domain near-infrared spectroscopy for enhanced sensitivity to brain tissue: First applications to human subjects.Journal of biophotonics · 2020Article
- Dual-slope method for enhanced depth sensitivity in diffuse optical spectroscopy.Journal of the Optical Society of America. A, Optics, image science, and vision · 2019Article
- Method to improve the depth sensitivity of diffuse reflectance measurements to absorption changes in optically turbid medium.Biomedical optics express · 2019Article
- Quantitative measurements of cerebral blood flow with near-infrared spectroscopy.Biomedical optics express · 2019Article
- Depth dependence of coherent hemodynamics in the human head.Journal of biomedical optics · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
We report a study on twenty-two healthy human subjects of the dynamic relationship between cerebral hemoglobin concentration ([HbT]), measured with near-infrared spectroscopy (NIRS) in the prefrontal cortex, and systemic arterial blood pressure (ABP), measured with finger plethysmography. [HbT] is a measure of local cerebral blood volume (CBV). We induced hemodynamic oscillations at discrete frequencies in the range 0.04-0.20 Hz with cyclic inflation and deflation of pneumatic cuffs wrapped around the subject's thighs. We modeled the transfer function of ABP and [HbT] in terms of effective arterial (K(a)) and venous (K(v)) compliances, and a cerebral autoregulation time constant (τ(AR)). The mean values (± standard errors) of these parameters across the twenty-two subjects were K(a) = 0.01 ± 0.01 μM/mmHg, K(v) = 0.09 ± 0.05 μM/mmHg, and τ(AR) = 2.2 ± 1.3 s. Spatially resolved measurements in a subset of eight subjects reveal a spatial variability of these parameters that may exceed the inter-subject variability at a set location. This study sheds some light onto the role that ABP and cerebral blood flow (CBF) play in the dynamics of [HbT] measured with NIRS, and paves the way for new non-invasive optical studies of cerebral blood flow and cerebral autoregulation.
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