Evidence map›Paper›PMID 30753113›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2019

Deletion of leptin receptors in vagal afferent neurons disrupts estrogen signaling, body weight, food intake and hormonal controls of feeding in female mice.

Kuei-Pin Huang, Charlotte C Ronveaux, Guillaume de Lartigue, Nori Geary, Lori Asarian, Helen E Raybould

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Kuei-Pin HuangDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis , Davis, California.
Charlotte C RonveauxDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis , Davis, California.
Guillaume de LartigueJohn B. Pierce Laboratory/Cellular and Molecular Physiology Department, Yale University School of Medicine , New Haven, Connecticut.
Nori GearyDepartment of Psychiatry, Weill Medical College of Cornell University , New York, New York.
Lori AsarianDepartment of Medicine-Immunobiology, Robert Larner College of Medicine, University of Vermont , Burlington, Vermont.
Helen E RaybouldDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis , Davis, California.
University of California, Davis · USCornell University · USUniversity of Vermont · USYale University · US

Funding

Mouse Metabolic Phenotyping Center (MMPC) at UC DavisU2CDK092993 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2016 to 2021
$5.9M
CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITYR01DK041004 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAYBOULD, HELEN E · 1995 to 2019
$5.4M
Mouse Metabolic Phenotyping Center (MMPC) at UC DavisU24DK092993 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2011 to 2015
$4.1M
The role of vagal afferent neurons in regulating feeding behaviorR00DK094871 · NIDDK · JOHN B. PIERCE LABORATORY, INC. · PI DE LARTIGUE, GUILLAUME FH · 2015 to 2017
$718k
NIDDK NIH HHS R00 DK094871NIDDK NIH HHS R01 DK041004NIDDK NIH HHS U24 DK092993NIDDK NIH HHS U2C DK092993
6 · The paper itself

Abstract

Deletion of the leptin receptor from vagal afferent neurons (VAN) using a conditional deletion (Nav1.8/LepR

Indexed as

AnimalsArcuate Nucleus of HypothalamusBody WeightCholecystokininDiet, High-FatEatingEnergy MetabolismEstradiolEstrogen Receptor alphaEstrogensFeeding BehaviorFemaleGhrelinMiceNeurons, AfferentObesityCholecystokininEsr1 protein, mouseEstradiolEstrogen Receptor alphaEstrogensGhrelinleptin receptor, mouseReceptors, Leptincholecystokininestradiolestrogen receptor 1leptin receptorvagal afferent

Identifiers

PMID30753113
PMCPMC6482667
OpenAlexW2913180775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.