Evidence map›Paper›PMID 30753065›Full record

ArticleJournal of the American Chemical Society2019

Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis.

James P Phelan, Simon B Lang, Jaehoon Sim, Simon Berritt, Andrew J Peat, Katelyn Billings, Lijun Fan, Gary A Molander

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Hydrocyclization/Defluorination of CFAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Chemodivergent alkylation of trifluoromethyl alkenesGreen chemistry : an international journal and green chemistry resource : GC · 2024
    Article
  14. FSOACS medicinal chemistry letters · 2024
    Article
  15. Article
  16. Mask and Release Strategy-Enabled Diversity-Oriented Synthesis for DNA-Encoded Library.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  17. Review
  18. Review
  19. Article
  20. On-DNA hydroalkylation ofChemical science · 2023
    Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

James P PhelanRoy and Diana Vagelos Laboratories, Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , United States.ORCID 0000-0002-0058-0653
Simon B LangRoy and Diana Vagelos Laboratories, Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , United States.ORCID 0000-0001-5380-2996
Jaehoon SimRoy and Diana Vagelos Laboratories, Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , United States.ORCID 0000-0001-7981-9892
Simon BerrittRoy and Diana Vagelos Laboratories, Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , United States.ORCID 0000-0001-5572-6771
Andrew J PeatGlaxoSmithKline , 1250 South Collegeville Road , Collegeville , Pennsylvania 19426 , United States.ORCID 0000-0003-4351-5541
Katelyn BillingsGlaxoSmithKline , 200 Cambridge Park Drive , Cambridge , Massachusetts 02140 , United States.ORCID 0000-0002-7483-8928
Lijun FanGlaxoSmithKline , 200 Cambridge Park Drive , Cambridge , Massachusetts 02140 , United States.ORCID 0000-0003-4381-4891
Gary A MolanderRoy and Diana Vagelos Laboratories, Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , United States.ORCID 0000-0002-9114-5584

Funding

Accessing New Chemical Space via Organic SynthesisR35GM131680 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MOLANDER, GARY A · 2019 to 2022
$2.4M
A Novel Mechanistic Paradigm for Cross-CouplingR01GM113878 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MOLANDER, GARY A · 2015 to 2018
$1.5M
Merging hydrogen atom transfer processes with photoredox/nickel dual catalysis for the selective functionalization of C(sp3)-H bondsF32GM125241 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI PHELAN, JAMES PATRICK · 2017 to 2018
$65k
NIGMS NIH HHS F32 GM125241NIGMS NIH HHS R01 GM113878NIGMS NIH HHS R35 GM131680
6 · The paper itself

Abstract

DNA-encoded library (DEL) technology is a powerful tool commonly used by the pharmaceutical industry for the identification of compounds with affinity to biomolecular targets. Success in this endeavor lies in sampling diverse chemical libraries. However, current DELs tend to be deficient in C(sp

Indexed as

Photochemical ProcessesSmall Molecule LibrariesAirAlkylationCatalysisDNAMolecular StructureNickelOxidation-ReductionDNANickelSmall Molecule Libraries

Identifiers

PMID30753065
PMCPMC6393171

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.