SynthesisPain2019
The medial temporal lobe in nociception: a meta-analytic and functional connectivity study.
Synthesis in Pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- Distinct Grey Matter Alterations in Untreated Mild to Moderate Chronic Low Back Pain: A Longitudinal Magnetic Resonance Imaging Study.European journal of pain (London, England) · 2026Observational
- Nr4a1 regulates microglia overactivation-mediated neuroinflammation to ameliorate cognitive impairment in trigeminal neuralgia rats.The journal of headache and pain · 2026Article
- Prediction of Postherpetic Neuralgia in Patients with Acute and Subacute Herpetic Neuralgia Using Structural Magnetic Resonance Imaging: A Retrospective Study.Pain and therapy · 2026Article
- Conducting Performance-Assisted Resections in the Right Temporo-Insular Cortex: A Real-Time Neuropsychological Testing (RTNT) Protocol.Brain sciences · 2025Article
- Temporal lobe dysfunction for comorbid depressive symptoms in postherpetic neuralgia patients.Brain communications · 2025Article
- Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific study.The journal of headache and pain · 2024Article
- Article
- Hippocampus diffusivity abnormalities in classical trigeminal neuralgia.Pain reports · 2024Article
- Effects of functional polymorphisms of opioid receptor mu 1 and catechol-O-methyltransferase on the neural processing of pain.Psychiatry and clinical neurosciences · 2024Article
- Altered habenular connectivity in chronic low back pain: An fMRI and machine learning study.Human brain mapping · 2023Article
- Functional connectivity of the language area in migraine: a preliminary classification model.BMC neurology · 2023Article
- Altered resting-state functional connectivity within corticostriatal and subcortical-striatal circuits in chronic pain.Scientific reports · 2022Article
- Hippocampal volume, FKBP5 genetic risk alleles, and childhood trauma interact to increase vulnerability to chronic multisite musculoskeletal pain.Scientific reports · 2022Article
- Reflections of the sensory findings in the central nervous system in patients with neuropathic pain.Experimental brain research · 2022Article
- Case report: The promising application of dynamic functional connectivity analysis on an individual with failed back surgery syndrome.Frontiers in neuroscience · 2022Article
- Amygdalar Functional Connectivity Differences Associated With Reduced Pain Intensity in Pediatric Peripheral Neuropathic Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Neuronal Dynamics of Pain in Parkinson's Disease.Brain sciences · 2021Article
- Differential Rearrangement of Excitatory Inputs to the Medial Prefrontal Cortex in Chronic Pain Models.Frontiers in neural circuits · 2021Review
- Burning Fog: Cognitive Impairment in Burning Mouth Syndrome.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Recent neuroimaging studies implicate the medial temporal lobe (MTL) in nociception and pain modulation. Here, we aim to identify which subregions of the MTL are involved in human pain and to test its connectivity in a cohort of chronic low-back pain patients (CBP). We conducted 2 coordinate-based meta-analyses to determine which regions within the MTL showed consistent spatial patterns of functional activation (1) in response to experimental pain in healthy participants and (2) in chronic pain compared with healthy participants. We followed PRISMA guidelines and performed activation likelihood estimate (ALE) meta-analyses. The first meta-analysis revealed consistent activation in the right anterior hippocampus (right antHC), parahippocampal gyrus, and amygdala. The second meta-analysis revealed consistently less activation in patients' right antHC, compared with healthy participants. We then conducted a seed-to-voxel resting state functional connectivity of the right antHC seed with the rest of the brain in 77 CBP and 79 age-matched healthy participants. We found that CBP had significantly weaker antHC functional connectivity to the medial prefrontal cortex compared with healthy participants. Taken together, these data indicate that the antHC has abnormally lower activity in chronic pain and reduced connectivity to the medial prefrontal cortex in CBP. Future studies should investigate the specific role of the antHC in the development and management of chronic pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.