Evidence map›Paper›PMID 30747825›Full record

ArticlePancreas2019

Association of Pancreatic Steatosis With Chronic Pancreatitis, Obesity, and Type 2 Diabetes Mellitus.

Temel Tirkes, Christie Y Jeon, Liang Li, Aron Y Joon, Ted A Seltman, Meghana Sankar, Scott A Persohn, Paul R Territo

Abstract read
In one paragraph

Article in Pancreas, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Temel Tirkes
Christie Y JeonSamuel Oschin Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Liang LiDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Aron Y JoonDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Ted A Seltman
Meghana Sankar
Scott A Persohn
Paul R Territo

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Indiana University (IU) Clinical Center for Chronic Pancreatitis Clinical Research NetworkU01DK108323 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Jeffrey James Easler, Evan L Fogel · 2015 to 2026
$6.5M
Pathophysiology, Epidemiology, and Prevention of Pancreatogenic Diabetes - Administrative SupplementU01DK108314 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Mark Goodarzi, Stephen J. Pandol · 2015 to 2026
$6.1M
Magnetic resonance Imaging as a Non-Invasive Method for Assessment of Pancreatic fibrosis (MINIMAP): a pilot studyR01DK116963 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI FOGEL, EVAN L, TIRKES, TEMEL · 2018 to 2020
$2.0M
Predicting the diagnosis of pancreatic cancer by leveraging big dataR21CA220073 · NCI · CEDARS-SINAI MEDICAL CENTER · PI JEON, CHRISTIE YOUNGHAE · 2018 to 2019
$429k
NCI NIH HHS P30 CA016672NCI NIH HHS R21 CA220073NIDDK NIH HHS R01 DK116963NIDDK NIH HHS U01 DK108314NIDDK NIH HHS U01 DK108323
6 · The paper itself

Abstract

objectiveThe aim of this study was to determine the association of the pancreatic steatosis with obesity, chronic pancreatitis (CP), and type 2 diabetes mellitus.

methodsPatients (n = 118) were retrospectively identified and categorized into no CP (n = 60), mild (n = 21), moderate (n = 27), and severe CP (n = 10) groups based on clinical history and magnetic resonance cholangiopancreatography using the Cambridge classification as the diagnostic standard. Visceral and subcutaneous compartments were manually segmented, and fat tissue was quantitatively measured on axial magnetic resonance imaging.

resultsPancreatic fat fraction showed a direct correlation with fat within the visceral compartment (r = 0.54). Patients with CP showed higher visceral fat (P = 0.01) and pancreatic fat fraction (P < 0.001): mild, 24%; moderate, 23%; severe CP, 21%; no CP group, 15%. Patients with type 2 diabetes mellitus showed higher pancreatic steatosis (P = 0.03) and higher visceral (P = 0.007) and subcutaneous fat (P = 0.004). Interobserver variability of measuring fat by magnetic resonance imaging was excellent (r ≥ 0.90-0.99).

conclusionsIncreased visceral adipose tissue has a moderate direct correlation with pancreatic fat fraction. Chronic pancreatitis is associated with higher pancreatic fat fraction and visceral fat. Type 2 diabetes mellitus is associated with higher pancreatic fat fraction and visceral and subcutaneous adiposity.

Indexed as

Adipose TissueAdultAgedAged, 80 and overCholangiopancreatography, Magnetic ResonanceDiabetes Mellitus, Type 2Fatty LiverFemaleHumansIntra-Abdominal FatMaleMiddle AgedObesityPancreasPancreatitis, ChronicRetrospective Studies

Identifiers

PMID30747825
PMCPMC6689133

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.