ReviewJournal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society2019
Do Most Patients With a Spontaneous Cerebrospinal Fluid Leak Have Idiopathic Intracranial Hypertension?
Review in Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Risk Reduction of Recurrent Cerebrospinal Fluid Leaks With Postoperative Intracranial Pressure Management: A Systematic Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Pooled it
- Prevalence of Venous Sinus Stenosis in Spontaneous Cerebrospinal Fluid Leak and the Role for Venous Sinus Stenting: A Systematic Review and Meta-Analysis.International forum of allergy & rhinology · 2025Pooled it
- Reduction of Cerebrospinal Fluid Leaks in Idiopathic Intracranial Hypertension with Glucagon-like Peptide-1 Receptor Agonist Use.Journal of neurological surgery. Part B, Skull base · 2026Article
- Spontaneous Middle Cranial Fossa Cerebrospinal Fluid Leaks and Intracranial Hypertension: Systematic Review With Meta-Analysis.Laryngoscope investigative otolaryngology · 2026Review
- Prelacrimal Recess-Pterygoid Window Approach to the Sphenoidal Lateral Recess Skull Base Defects.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Venous Sinus Stenting for Cerebrospinal Fluid Leaks in Setting of Idiopathic Intracranial Hypertension-An Institutional Series and Systematic Review of Literature.Journal of neurological surgery. Part B, Skull base · 2026Article
- Utility of intracranial pressure monitoring in idiopathic intracranial hypertension patients with refractory headaches: an 8-year, single-surgeon, specialized-center retrospective study.Neurosurgical focus · 2026Article
- Diagnosing idiopathic intracranial hypertension in patients with spontaneous cerebrospinal fluid rhinorrhoea: the growing significance of neuroradiological criteria.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Intradural Repair of Temporal Bone Encephalocele and Cerebrospinal Fluid Leak: Results from a Single Institution.Journal of neurological surgery. Part B, Skull base · 2025Article
- Exploratory operation in a patient with spontaneous temporal bone cerebrospinal fluid leaks: A case report.World journal of clinical cases · 2025Article
- Contemporary Management of Cerebrospinal Fluid Rhinorrhoea: A Review of the Literature.Journal of clinical medicine · 2025Review
- Deep learning to predict risk of lateral skull base cerebrospinal fluid leak or encephalocele.International journal of computer assisted radiology and surgery · 2024Article
- Atypical Presentation of Idiopathic Intracranial Hypertension: A Case Series and Literature Review.Asian journal of neurosurgery · 2024Article
- Rebound Intracranial Hypertension.Current pain and headache reports · 2024Review
- Lumbar puncture increases Alzheimer's disease biomarker levels in cerebrospinal fluid of rhesus monkeys.iScience · 2024Article
- Spontaneous cerebrospinal fluid rhinorrhea as a primary presentation of idiopathic intracranial hypertension, management strategies, and clinical outcome.Surgical neurology international · 2024Article
- Combined surgical repair and venous sinus stenting for patients with skull base encephaloceles secondary to dural venous sinus stenosis.Acta neurochirurgica · 2023Article
- The expanding spectrum of idiopathic intracranial hypertension.Eye (London, England) · 2023Review
- Spontaneous Cerebrospinal Fluid Rhinorrhea Secondary to Idiopathic Intracranial Hypertension.Cureus · 2023Article
- Remote cerebellar hemorrhage following repeated lumbar punctures.BMC neurology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe association between cerebrospinal fluid (CSF) leaks at the skull base and raised intracranial pressure (ICP) has been reported since the 1960s. It has been suggested that spontaneous CSF leaks might represent a variant of idiopathic intracranial hypertension (IIH). We review the evidence regarding the association between spontaneous CSF leaks and IIH, and the role of ICP in the pathophysiology of nontraumatic skull base defects. We also discuss the management of ICP in the setting of CSF leaks and IIH. EVIDENCE ACQUISITION: References were identified by searches of PubMed from 1955 to September 2018 with the terms "idiopathic intracranial hypertension" and "cerebrospinal fluid leak." Additional references were identified using the terms "pseudotumor cerebri," "intracranial hypertension," "benign intracranial hypertension," and by hand search of relevant articles.
resultsA CSF leak entails the egress of CSF from the subarachnoid spaces of the skull base into the surrounding cavitary structures. Striking overlaps exist regarding demographic, clinical, and radiological characteristics between IIH patients and those with spontaneous CSF leaks, suggesting that some (if not most) of these patients have IIH. However, determining whether a patient with spontaneous CSF leak may have IIH may be difficult, as signs and symptoms of raised ICP may be obviated by the leak. The pathophysiology is unknown but might stem from progressive erosion of the thin bone of the skull base by persistent pulsatile high CSF pressure. Currently, there is no consensus regarding the management of ICP after spontaneous CSF leak repair when IIH is suspected.
conclusionsIIH is becoming more widely recognized as a cause of spontaneous CSF leaks, but the causal relationship remains poorly characterized. Systematic evaluation and follow-up of patients with spontaneous CSF leaks by neuro-ophthalmologists will help clarify the relation between IIH and spontaneous CSF leaks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.