Evidence map›Paper›PMID 30747396›Full record

ArticleCardiovascular drugs and therapy2019

Activation of T Lymphocytes as a Novel Mechanism in Beta1-Adrenergic Receptor Autoantibody-Induced Cardiac Remodeling.

Yunhui Du, Xiao Li, Haicun Yu, Li Yan, Wayne Bond Lau, Shihan Zhang, Yanwen Qin, Wen Wang, Xinliang Ma, Huirong Liu and 1 more

Abstract read
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In one paragraph

Article in Cardiovascular drugs and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Diagnostic and prognostic value of autoantibodies against βExperimental and therapeutic medicine · 2020
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Yunhui DuBeijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, 100029, China.
Xiao LiDepartment of Pathology, School of Basic Medical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Haicun YuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Li YanDepartment of pathophysiology, Institute of Basic Medical Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Wayne Bond LauDepartment of Emergency Medicine, Thomas Jefferson University, 1025 Walnut Street, College Building, Suite 808, Philadelphia, PA, 19107, USA.
Shihan ZhangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Yanwen QinBeijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, 100029, China.
Wen WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Xinliang MaBeijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, Ministry of Education, Capital Medical University, Beijing, 100069, China.
Huirong LiuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. liuhr2000@126.com.
Michael FuDepartment of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, 416 50, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNumerous studies have reported significantly elevated titers of serum autoantibody against the second extracellular loop of β METHODS AND

resultsβ

conclusionsCollectively, we demonstrate that β

Indexed as

Lymphocyte ActivationVentricular Function, LeftVentricular RemodelingAgedAged, 80 and overAnimalsApoptosisAutoantibodiesCell ProliferationCells, CulturedDisease Models, AnimalFemaleHeart FailureHumansInterleukin-6MaleADRB1 protein, humanAdrb1 protein, mouseAutoantibodiesIL6 protein, humanInterleukin-6interleukin-6, mouseReceptors, Adrenergic, beta-1AutoantibodyBeta-1Receptors adrenergicRemodelingT lymphocytes

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.