Evidence map›Paper›PMID 30747382›Full record

ArticleMolecular biotechnology2019

Biochemical, Kinetic, and Computational Structural Characterization of Shikimate Kinase from Methicillin-Resistant Staphylococcus aureus.

Alejandro Favela-Candia, Alfredo Téllez-Valencia, Mara Campos-Almazán, Erick Sierra-Campos, Mónica Valdez-Solana, Jesús Oria-Hernández, Adriana Castillo-Villanueva, Hugo Nájera, Claudia Avitia-Domínguez

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Inhibition of Shikimate Kinase from Methicillin-ResistantInternational journal of molecular sciences · 2024
    Article
  2. Article
  3. Article
  4. Molecules (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Alejandro Favela-CandiaFacultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango, Av. Universidad y Fanny Anitua S/N, C.P. 34000, Durango, Dgo, Mexico.
Alfredo Téllez-ValenciaFacultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango, Av. Universidad y Fanny Anitua S/N, C.P. 34000, Durango, Dgo, Mexico.
Mara Campos-AlmazánFacultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango, Av. Universidad y Fanny Anitua S/N, C.P. 34000, Durango, Dgo, Mexico.
Erick Sierra-CamposFacultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Av. Artículo 123 S/N Fracc. Filadelfia, Gómez Palacio, C.P. 35010, Durango, Mexico.
Mónica Valdez-SolanaFacultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Av. Artículo 123 S/N Fracc. Filadelfia, Gómez Palacio, C.P. 35010, Durango, Mexico.
Jesús Oria-HernándezLaboratorio de Bioquímica Genética, Secretaría de Salud, Instituto Nacional de Pediatría, C.P. 04534, Ciudad de México, Mexico.
Adriana Castillo-VillanuevaLaboratorio de Bioquímica Genética, Secretaría de Salud, Instituto Nacional de Pediatría, C.P. 04534, Ciudad de México, Mexico.
Hugo NájeraDepartamento de Ciencias Naturales, Universidad Autónoma Metropolitana, Unidad Cuajimalpa, Delegación Cuajimalpa de Morelos, Av. Vasco de Quiroga 4871, Colonia Santa Fe Cuajimalpa, C.P. 05300, Ciudad de México, Mexico.
Claudia Avitia-DomínguezFacultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango, Av. Universidad y Fanny Anitua S/N, C.P. 34000, Durango, Dgo, Mexico. avitiaclaudia@gmail.com.
Universidad Juárez del Estado de Durango · MXInstituto Nacional de Pediatria · MXUniversidad Autónoma Metropolitana · MX

Funding

Consejo Nacional de Ciencia y Tecnología 257848Consejo Nacional de Ciencia y Tecnología 258694
6 · The paper itself

Abstract

One of the most widespread pathogens worldwide is methicillin-resistant Staphylococcus aureus, a bacterium that provokes severe life-threatening illnesses both in hospitals and in the community. The principal challenge lies in the resistance of MRSA to current treatments, which encourages the study of different molecular targets that could be used to develop new drugs against this infectious agent. With this goal, a detailed characterization of shikimate kinase from this microorganism (SaSK) is described. The results showed that SaSK has a K

Indexed as

Adenosine TriphosphateDrug DesignEnzyme StabilityKineticsMethicillin-Resistant Staphylococcus aureusModels, MolecularMolecular Dynamics SimulationPhosphotransferases (Alcohol Group Acceptor)Protein BindingProtein ConformationProtein FoldingShikimic AcidStructural Homology, ProteinAdenosine TriphosphatePhosphotransferases (Alcohol Group Acceptor)shikimate kinaseShikimic AcidEnzyme kineticsHomology modelingMolecular dynamicsMRSAShikimate kinase

Identifiers

PMID30747382
OpenAlexW2913282244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.