Evidence map›Paper›PMID 30747311›Full record

Trial reportJournal of neural transmission (Vienna, Austria : 1996)2019

Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence.

M Sebold, G Spitta, T Gleich, T Dembler-Stamm, O Butler, K Zacharias, S Aydin, M Garbusow, M Rapp, F Schubert and 3 more

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neural transmission (Vienna, Austria : 1996), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The Dopamine System in Mediating Alcohol Effects in Humans.Current topics in behavioral neurosciences · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

M SeboldDepartment of Psychiatry and Psychotherapy, Charité Campus Mitte (CCM), Charité- Universitätsmedizin Berlin, Berlin, Germany. gianna.spitta@charite.de.
G SpittaDepartment of Psychiatry and Psychotherapy, Charité Campus Mitte (CCM), Charité- Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-9222-3591
T GleichDepartment of Psychiatry and Psychotherapy, Charité Campus Mitte (CCM), Charité- Universitätsmedizin Berlin, Berlin, Germany.
T Dembler-StammDepartment of Psychiatry and Psychotherapy, Charité Campus Mitte (CCM), Charité- Universitätsmedizin Berlin, Berlin, Germany.
O ButlerCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
K ZachariasDepartment of Psychiatry and Psychotherapy, Charité Campus Mitte (CCM), Charité- Universitätsmedizin Berlin, Berlin, Germany.
S AydinPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig, Berlin, Germany.
M GarbusowDepartment of Psychiatry and Psychotherapy, Charité Campus Mitte (CCM), Charité- Universitätsmedizin Berlin, Berlin, Germany.
M RappDepartment for Social and Preventive Medicine, University of Potsdam, Potsdam, Germany.
F SchubertPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig, Berlin, Germany.
R BuchertDepartment of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
J GallinatDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
A HeinzDepartment of Psychiatry and Psychotherapy, Charité Campus Mitte (CCM), Charité- Universitätsmedizin Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress plays a key role in modulating addictive behavior and can cause relapse following periods of abstinence. Common effects of stress and alcohol on the dopaminergic system have been suggested, although the precise mechanisms are unclear. Here, we investigated 20 detoxified alcohol-dependent patients and 19 matched healthy controls and assessed striatal D2/D3 availability using [

Indexed as

AdultAlcoholismBenzamidesFemaleHumansMaleMiddle AgedPositron-Emission TomographyPyrrolidinesReceptors, Dopamine D2Receptors, Dopamine D3Stress, PsychologicalBenzamidesN-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamidePyrrolidinesReceptors, Dopamine D2Receptors, Dopamine D3Alcohol dependenceDopamine D2/D3 receptorPositron emission tomographyStressful life eventsStriatum

Identifiers

PMID30747311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.