Evidence map›Paper›PMID 30747271›Full record

ArticleEuropean journal of nutrition2020

Reduced meal frequency alleviates high-fat diet-induced lipid accumulation and inflammation in adipose tissue of pigs under the circumstance of fixed feed allowance.

Honglin Yan, Shanchuan Cao, Yan Li, Hongfu Zhang, Jingbo Liu

Abstract read
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In one paragraph

Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 45 citations in OpenAlex.

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  6. Exploring the Effect of GastrointestinalAnimals : an open access journal from MDPI · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Honglin YanSchool of Life Science and Engineering, Southwest University of Science and Technology, 621010, Mianyang, People's Republic of China.
Shanchuan CaoSchool of Life Science and Engineering, Southwest University of Science and Technology, 621010, Mianyang, People's Republic of China.
Yan LiSchool of Life Science and Engineering, Southwest University of Science and Technology, 621010, Mianyang, People's Republic of China.
Hongfu ZhangState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, 100193, Beijing, People's Republic of China.
Jingbo LiuSchool of Life Science and Engineering, Southwest University of Science and Technology, 621010, Mianyang, People's Republic of China. liuswust@163.com.
Southwest University of Science and Technology · CNChinese Academy of Agricultural Sciences · CNInstitute of Animal Sciences · CN

Funding

National Natural Science Foundation of China 31802069Sichuan Science and Technology Program 2018JY0225
6 · The paper itself

Abstract

purposeThe present study was conducted to determine whether reduced meal frequency (MF) could restore high-fat diet (HFD)-modified phenotypes and microbiota under the condition of fixed feed allowance.

methodsA total of 32 barrows with initial weight of 61.6 ± 0.8 kg were assigned to two diets [control diet (CON) versus HFD] and two meal frequencies [12 equal meals/day (M12) versus 2 equal meals/day (M2)], the trial lasted 8 weeks. The lipid metabolism and inflammatory response in adipose tissue as well as the profiles of intestinal microbiota and bacterial-derived metabolites were determined.

resultsM2 versus M12 feeding regimen decreased perirenal fat weight and serum triglyceride and liposaccharide (LPS) concentrations in HFD-fed pigs (P < 0.05). Reduced MF down-regulated mRNA expression of lipoprotein lipase, CD36 molecule, interleukin 1 beta, tumor necrosis factor alpha, toll-like receptor 4, myeloid differentiation factor 88 (MYD88), and nuclear factor kappa beta 1 as well as protein expression of MYD88 in perirenal fat of HFD-fed pigs (P < 0.05). M2 feeding regimen increased abundance of Prevotella and decreased abundance of Bacteroides in colonic content of HFD-fed pigs (P < 0.05). No difference in short-chain fatty acids (SCFAs) profile in colonic content was observed among four groups (P > 0.05).

conclusionOur results suggested that M2 versus M12 feeding regimen ameliorated HFD-induced fat deposition and inflammatory response by decreasing fatty acid uptake and deactivating LPS/TLR4 signaling pathway in adipose tissue and restoring microbiota composition in distal intestine, without affecting SCFAs profile in distal luminal content.

Indexed as

Adipose TissueAnimalsDiet, High-FatDisease Models, AnimalFeeding BehaviorInflammationLipid MetabolismLipidsSwineLipidsHigh-fat dietInflammationLipid metabolismMeal frequencyMicrobiotaShort-chain fatty acids

Identifiers

PMID30747271
OpenAlexW2912550132

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.