Evidence map›Paper›PMID 30746940›Full record

ArticleChemical research in toxicology2019

Oxanosine Monophosphate Is a Covalent Inhibitor of Inosine 5'-Monophosphate Dehydrogenase.

Runhan Yu, Youngchang Kim, Natalia Maltseva, Philip Braunstein, Andrzej Joachimiak, Lizbeth Hedstrom

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A journey into the regulatory secrets of theFrontiers in pharmacology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Runhan YuDepartment of Chemistry , Brandeis University , Waltham , Massachusetts 02454 , United States.ORCID 0000-0003-0721-9374
Youngchang KimStructural Biology Center, Biosciences , Argonne National Laboratory , Argonne , Illinois 60439 , United States.
Natalia MaltsevaCenter for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering , University of Chicago , Chicago , Illinois 60637 , United States.
Philip BraunsteinDepartment of Biochemistry , Brandeis University , Waltham , Massachusetts 02454 , United States.
Andrzej JoachimiakStructural Biology Center, Biosciences , Argonne National Laboratory , Argonne , Illinois 60439 , United States.
Lizbeth HedstromDepartment of Chemistry , Brandeis University , Waltham , Massachusetts 02454 , United States.ORCID 0000-0001-8432-3322

Funding

INOSINE MONOPHOSPHATE DEHYDROGENASER01GM054403 · NIGMS · BRANDEIS UNIVERSITY · PI HEDSTROM, LIZBETH K. · 1998 to 2016
$4.2M
NIAID NIH HHS HHSN272201200026CNIAID NIH HHS HHSN272201700060CNIGMS NIH HHS R01 GM054403
6 · The paper itself

Abstract

Reactive nitrogen species (RNS) are produced during infection and inflammation, and the effects of these agents on proteins, DNA, and lipids are well recognized. In contrast, the effects of RNS damaged metabolites are less appreciated. 5-Amino-3-β-(d-ribofuranosyl)-3 H-imidazo-[4,5- d][1,3]oxazine-7-one (oxanosine) and its nucleotides are products of guanosine nitrosation. Here we demonstrate that oxanosine monophosphate (OxMP) is a potent reversible competitive inhibitor of IMPDH. The value of K

Indexed as

Enzyme InhibitorsHumansIMP DehydrogenaseMolecular StructurePhosphatesRibonucleosidesEnzyme InhibitorsIMP DehydrogenaseoxanosinePhosphatesRibonucleosides

Identifiers

PMID30746940
PMCPMC6467267

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.