ArticleAging cell2019
Conservation of physiological dysregulation signatures of aging across primates.
Article in Aging cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Entropy and Human Aging.Aging cell · 2025Article
- No winners or losers: clinical chemistry-based biological aging metrics perform similarly across cohorts and health outcomes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Stage-specific metabolic allocation: nutrient investment strategies duringFrontiers in nutrition · 2025Article
- Does diet influence aging? Evidence from animal studies.Journal of internal medicine · 2024Review
- Age-related physiological dysregulation progresses slowly in semi-free-ranging chimpanzees.Evolution, medicine, and public health · 2024Article
- Physiological Dysregulation Proceeds and Predicts Health Outcomes Similarly in Chinese and Western Populations.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Explainable machine learning framework to predict personalized physiological aging.Aging cell · 2023Article
- Body mass and growth rates in captive chimpanzees (Pan troglodytes) cared for in African wildlife sanctuaries, zoological institutions, and research facilities.Zoo biology · 2023Article
- Interactions between genes involved in physiological dysregulation and axon guidance: role in Alzheimer's disease.Frontiers in genetics · 2023Article
- Evolutionary Approaches in Aging Research.Cold Spring Harbor perspectives in medicine · 2022Review
- A complex systems approach to aging biology.Nature aging · 2022Review
- Aging gut microbiota of wild macaques are equally diverse, less stable, but progressively personalized.Microbiome · 2022Article
- An objective metric of individual health and aging for population surveys.Population health metrics · 2022Article
- Modular Evolution of the Drosophila Metabolome.Molecular biology and evolution · 2022Article
- Review
- A holistic approach to predicting diabetes risk via biomarkers.EBioMedicine · 2021Article
- Urinary neopterin of wild chimpanzees indicates that cell-mediated immune activity varies by age, sex, and female reproductive status.Scientific reports · 2021Article
- Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity.Mechanisms of ageing and development · 2021Review
- Evidence from two cohorts for the frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems.Biogerontology · 2021Article
- Robust Physiological Metrics From Sparsely Sampled Networks.Frontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Two major goals in the current biology of aging are to identify general mechanisms underlying the aging process and to explain species differences in aging. Recent research in humans suggests that one important driver of aging is dysregulation, the progressive loss of homeostasis in complex biological networks. Yet, there is a lack of comparative data for this hypothesis, and we do not know whether dysregulation is widely associated with aging or how well signals of homeostasis are conserved. To address this knowledge gap, we use unusually detailed longitudinal biomarker data from 10 species of nonhuman primates housed in research centers and data from two human populations to test the hypotheses that (a) greater dysregulation is associated with aging across primates and (b) physiological states characterizing homeostasis are conserved across primates to degrees associated with phylogenetic proximity. To evaluate dysregulation, we employed a multivariate distance measure, calculated from sets of biomarkers, that is associated with aging and mortality in human populations. Dysregulation scores positively correlated with age and risk of mortality in most nonhuman primates studied, and signals of homeostatic state were significantly conserved across species, declining with phylogenetic distance. Our study provides the first broad demonstration of physiological dysregulation associated with aging and mortality risk in multiple nonhuman primates. Our results also imply that emergent signals of homeostasis are evolutionarily conserved, although with notable variation among species, and suggest promising directions for future comparative studies on dysregulation and the aging process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.