ArticleBreast cancer research and treatment2019
The effect of chemotherapy on subjective cognitive function in younger early-stage breast cancer survivors treated with chemotherapy compared to older patients.
Article in Breast cancer research and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Experiences of Cancer-Related Cognitive Impairment Across Cancer Types: Qualitative Systematic Review.JMIR cancer · 2025Pooled it
- "I had to work it out for myself": opportunities for primary care to fill a void for early-onset breast cancer survivors.Journal of cancer survivorship : research and practice · 2026Article
- Cancer survivors' attitudes toward service delivery formats for interventions targeting cognitive impairments: a survey study.BMC health services research · 2026Article
- Caffeine attenuates cisplatin induced microglial reactivity and cognitive dysfunction.Frontiers in molecular neuroscience · 2026Article
- Long-term health-related quality of life among adolescent and young adult breast cancer survivors.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Impact of nonpharmacological interventions on cognitive impairment in women with breast cancer: A systematic review and meta-analysis.Asia-Pacific journal of oncology nursing · 2023Review
- Association of cognitive impairment and breast cancer survivorship on quality of life in younger breast cancer survivors.Journal of cancer survivorship : research and practice · 2022Article
- Self-perceived cognitive functioning and quality of life among cancer survivors: results from the PROFILES registry.Journal of cancer survivorship : research and practice · 2022Article
- Aging and CNS Myeloid Cell Depletion Attenuate Breast Cancer Brain Metastasis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021Article
- Changes in Attentional Function in Patients From Before Through 12 Months After Breast Cancer Surgery.Journal of pain and symptom management · 2020Article
- Antineoplastic drugs prescription during visits by adult cancer patients with comorbidities: findings from the 2010-2016 National Ambulatory Medical Care Survey.Cancer causes & control : CCC · 2020Article
- COVID-19 Lockdown and Its Adverse Impact on Psychological Health in Breast Cancer.Frontiers in psychology · 2020Article
- Cognitive Functioning and Psychological Well-being in Breast Cancer Patients on Endocrine Therapy.In vivo (Athens, Greece)Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the impact of chemotherapy on subjective cognitive functioning according to age in a large cohort of breast cancer patients.
methodsWithin the UMBRELLA cohort, 715 patients with early-stage primary invasive breast cancer (T1-3N0-1M0) were selected. Subjective cognitive function was assessed by means of the EORTC QLQ-C30 up to 24 months and compared between patients treated with and without chemotherapy, for three different age strata (355 patients < 55 years, 240 patients aged 55-65 years, and 120 patients > 65 years). Differences between chemotherapy and non-chemotherapy patients by age at different time points were assessed by linear mixed-effect models correcting for age, tumor stage, educational level, endocrine therapy, anxiety, and depression.
resultsIn total, 979 patients from the UMBRELLA cohort were included, of which 715 (73%) responded to baseline and at least one follow-up questionnaire. Questionnaire response rates ranged between 92 and 70%. The proportion of patients treated with chemotherapy decreased with age: 64% (n = 277) in patients < 55 years, 45% (n = 107) in patients 55-65 years, and 23% (n = 27) in patients > 65 years. Chemotherapy was associated with reduced subjective cognitive functioning. The impact of chemotherapy on subjective cognitive function was most pronounced in patients < 55 years, followed by those between 55 and 65 years. In the youngest age groups, patients treated with chemotherapy had significantly lower cognitive functioning up to 24 months. In women over 65 years, subjective cognitive functioning was comparable between patients treated with and without chemotherapy.
conclusionThis study confirms that chemotherapy is associated with impaired subjective self-reported cognitive functioning in breast cancer patients, and the effect persists at least up to 2 years after diagnosis. The impact of chemotherapy on self-reported cognitive functioning in the first 24 months is most pronounced in younger patients, especially those under 55 years of age.
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