Evidence map›Paper›PMID 30746617›Full record

ArticleJournal of physiology and biochemistry2019

THBS4 predicts poor outcomes and promotes proliferation and metastasis in gastric cancer.

Xiangbo Chen, Yisen Huang, Yubin Wang, Qiuli Wu, Shunzhong Hong, Zicheng Huang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of physiology and biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

  1. Multimodal features and prognostic risk assessment in locally advanced gastric cancer patients following neoadjuvant therapy based on machine learning algorithms: a multicenter study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
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  8. Pathophysiological roles of thrombospondin-4 in disease development.Seminars in cell & developmental biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiangbo ChenEndoscopy Center, The First Hospital of Quanzhou Affiliated to Fujian Medical University, No.250 East Street, Licheng District, Quanzhou, 362000, Fujian Province, China.
Yisen HuangDepartment of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, No.250 East Street, Licheng District, Quanzhou, 362000, Fujian Province, China.
Yubin WangDepartment of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, No.250 East Street, Licheng District, Quanzhou, 362000, Fujian Province, China.
Qiuli WuEndoscopy Center, The First Hospital of Quanzhou Affiliated to Fujian Medical University, No.250 East Street, Licheng District, Quanzhou, 362000, Fujian Province, China.
Shunzhong HongEndoscopy Center, The First Hospital of Quanzhou Affiliated to Fujian Medical University, No.250 East Street, Licheng District, Quanzhou, 362000, Fujian Province, China.
Zicheng HuangDepartment of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, No.250 East Street, Licheng District, Quanzhou, 362000, Fujian Province, China. hzcpwmdyyy@126.com.
Fujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC), a common and lethal cancer in the world, has a high risk of metastasis. Our study was to explore the effects of THBS4 on GC progress and metastasis and the underlying mechanisms. The proliferations of MGC-803 and BGC-823 cells were analyzed via cell count, MTT, and soft agar colony formation assay. The migration and invasion of transfected GC cells was investigated via transwell migration and invasion assay. The mRNA abundance of THBS4 and KLF9 was detected by quantitative real-time PCR (qPCR). The analysis of Gene Expression Omnibus (GEO) dataset (GSE26253) suggested that THBS4 was up-regulated in recurrent GC patients and was positively correlated with the increase in pathological stage and poor prognosis in GC. THBS4 stimulated the proliferations of GC cells. Moreover, THBS4 overexpression fostered the migration and invasion of GC cells. Further, the bioinformatics analysis of the cancer genome atlas dataset suggested that there may be a positive correlation between THBS4 and KLF9 expression. QPCR analysis proved that transfected with THBS4 overexpression plasmid enhanced KLF9 expression in GC cells. THBS4 mRNA and protein expression were up-regulated in MGC-803 and BGC-823 cells compared to those in non-tumoral gastric cells. KLF9 overexpression significantly stimulated the proliferation and metastasis of MGC-803 and BGC-823 cells. Besides, KLF9 siRNA inhibited the enhanced viability, migration, and invasion of MGC-803 cells caused by the transfection with THBS4 overexpression plasmid. In conclusion, THBS4 had positive effects on GC proliferation and metastasis via targeting KLF9.

Indexed as

Gene Expression Regulation, NeoplasticBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationComputational BiologyDatabases, FactualDatasets as TopicDiffusion Chambers, CultureHumansKruppel-Like Transcription FactorsLymphatic MetastasisNeoplasm InvasivenessNeoplasm Recurrence, LocalPrognosisStomach NeoplasmsBiomarkers, TumorKLF9 protein, humanKruppel-Like Transcription Factorsthrombospondin 4ThrombospondinsGastric cancerKLF9MetastasisProliferationTHBS4

Identifiers

PMID30746617
OpenAlexW2912726271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.