Evidence map›Paper›PMID 30746559›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019

Attenuation of ALS progression during pregnancy-lessons to be learned or just a coincidence?

Mirea Hancevic, Hrvoje Bilic, Barbara Sitas, Gordana Pavlisa, Fran Borovecki, Ivana Munitic, Ervina Bilic

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Clinical characteristics, course, and outcomes of amyotrophic lateral sclerosis overlapping with pregnancy: a systematic review of 38 published cases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Pooled it
  2. Review
  3. Article
  4. Fulminant amyotrophic lateral sclerosis manifesting in a young woman during pregnancy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
  5. Rare Neurologic Diseases and Neurological Sciences: a report for the celebration of the 2020 Rare Diseases Day.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mirea HancevicDepartment of Neurology, Clinical Hospital Centre Zagreb, Kispaticeva 12, 10000, Zagreb, Croatia. mhancevic@gmail.com.ORCID http://orcid.org/0000-0002-7558-1749
Hrvoje BilicDepartment of Neurology, Clinical Hospital Centre Zagreb, Kispaticeva 12, 10000, Zagreb, Croatia.
Barbara SitasDepartment of Neurology, Clinical Hospital Centre Zagreb, Kispaticeva 12, 10000, Zagreb, Croatia.
Gordana PavlisaDepartment of Pulmonology, Clinical Hospital Centre Zagreb, Kispaticeva 12, 10000, Zagreb, Croatia.
Fran BoroveckiDepartment of Neurology, Clinical Hospital Centre Zagreb, Kispaticeva 12, 10000, Zagreb, Croatia.
Ivana MuniticLaboratory of Molecular Immunology, Department of Biotechnology, University of Rijeka, Radmile Matejcic 2, 51000, Rijeka, Croatia.
Ervina BilicDepartment of Neurology, Clinical Hospital Centre Zagreb, Kispaticeva 12, 10000, Zagreb, Croatia.
University Hospital Centre Zagreb · HRUniversity of Rijeka · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ALS is the most frequent motor neuron disorder in adults with suggested complex relationship regarding gender. Studies investigating ALS and hormones have provided varying results. ALS onset during pregnancy is uncommon and pregnancy after the ALS symptom onset is even rarer. We present three patients with the onset of ALS symptoms before or during pregnancy and propose a putative disease modifying mechanism leading to attenuation of disease progression that we observed during the pregnancies.

Indexed as

Disease ProgressionPregnancy ComplicationsAmyotrophic Lateral SclerosisFemaleHumansPregnancyALSFUSGenderHormonesImmunomodulationPregnancy

Identifiers

PMID30746559
OpenAlexW2912787507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.