Evidence map›Paper›PMID 30746507›Full record

ArticleJournal of the Endocrine Society2019

Wnt Pathway Inhibitor DKK1: A Potential Novel Biomarker for Adiposity.

Hira Ali, Joseph M Zmuda, Ryan K Cvejkus, Erin E Kershaw, Allison L Kuipers, Elizabeth A Oczypok, Victor Wheeler, Clareann H Bunker, Iva Miljkovic

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

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  15. Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study.International journal of environmental research and public health · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hira AliDivision of Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0001-9563-2403
Joseph M ZmudaDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Ryan K CvejkusDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Erin E KershawDivision of Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Allison L KuipersDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Elizabeth A OczypokDivision of Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Victor WheelerTobago Health Studies Office, Scarborough, Tobago, Trinidad & Tobago, West Indies.
Clareann H BunkerDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Iva MiljkovicDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-3155-9777
University of Pittsburgh · USUniversity of Trinidad and Tobago · TT

Funding

T32 Research Training in Diabetes and EndocrinologyT32DK007052 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBERT M O'DOHERTY · 1986 to 2026
$6.3M
Epidemiology of Bone Loss in African MenR01AR049747 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZMUDA, JOSEPH M. · 2003 to 2014
$5.9M
DRUG ABUSE RESEARCH TRAINING PROGRAMT32DA007252 · NIDA · MC LEAN HOSPITAL (BELMONT, MA) · PI MELLO, NANCY K. · 1991 to 2011
$3.0M
Ectopic adiposity in black men with high type 2 diabetes riskR01DK097084 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MILJKOVIC, IVA · 2013 to 2016
$1.9M
Wnt Genes and Skeletal Aging: From the Population to the CellR01AG033618 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZMUDA, JOSEPH M. · 2010 to 2012
$1.9M
Molecular Epidemiology of the Wnt Pathway in Subclinical Cardiovascular DiseaseK01HL125658 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KUIPERS, ALLISON L · 2015 to 2019
$693k
NHLBI NIH HHS K01 HL125658NIAMS NIH HHS R01 AR049747NIA NIH HHS R01 AG033618NIDA NIH HHS T32 DA007252NIDDK NIH HHS R01 DK097084NIDDK NIH HHS T32 DK007052
6 · The paper itself

Abstract

Emerging evidence indicates that ectopic skeletal muscle adiposity may be a risk factor for type 2 diabetes (T2D), especially in persons of African ancestry.

Indexed as

adiposityAfrican ancestryDKK1muscle densityskeletal muscleWNT

Identifiers

PMID30746507
PMCPMC6364619
OpenAlexW2907481244

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.